The inclusive term that describes all of the DNA in the nucleus of a cell is its
A. genome.
B. chromosome.
C. gene.
D. proteome.
A
The relative location of genes on a chromosome as determined by recombination frequencies is illustrated in a _______ map.
A. DNA
B. genetic
C. chromosomal
D. physical
B
Using actual landmarks within DNA sequences, scientists can generate a _______ map.
A. genetic
B. DNA
C. physical
D. chromosomal
C
Distances on a genetic map are measured in _____ units.
A. centromere
B. DNA
C. dalton
D. centimorgan
D
Silent copies of genes that have been inactivated by mutations are called
A. pseudogenes.
B. clones.
C. exons.
D. introns.
A
A human gene is composed of numerous fragments of protein-encoding information known as _______.
A. DNA
B. mRNA
C. exons
D. introns
C
The ends of chromosomes are called ________.
A. telomeres
B. centromeres
C. caps
D. DNA termini
A
Mobile bits of DNA that can jump from one location on a chromosome to another location are called
A. simple sequence repeats.
B. transposons.
C. exons.
D. introns.
E. pseudogenes.
B
Sequences of DNA assembled by identifying overlaps among smaller DNA segments are known as
A. single strand polymorphisms.
B. synteny.
C. draft sequences.
D. proteome.
E. contig.
E
Conserved arrangements of segments of DNA in related genomes are referred to as
A. synteny.
B. homology.
C. analogous DNA.
D. a contig.
E. a comparative genome.
A
Mitochondria and chloroplasts are bacterial relatives living within eukaryotes as a result of
A. synteny.
B. exosymbiosis.
C. endosymbiosis.
D. draft sequencing by the nucleosome.
E. contiguous base pairing.
C
A defining characteristic of draft sequences is that they have
A. many gaps in regions of highly repetitive DNA.
B. less than 1 error in 10,000 nucleotides.
C. been found in various proteomes across the eukaryote life forms.
D. been produced by alternativ
A
Your research team is challenged with the quantification of all RNAs present in cells and tissues post exposure to exercise. The primary focus of your inquiry would be
A. proteomes.
B. spliceosomes.
C. nucleosomes.
D. RNA motifs.
E. transcriptomes.
E
A transgene is best described as
A. hard to destroy once inserted into a genome.
B. hard to study because of its transposons.
C. created by several of the DNA motifs.
D. an inserted foreign gene.
E. a result of endosymbiosis.
D
The most significant reason for a chloroplast's ability to replicate independently is because
A. of synteny.
B. it has its own genome.
C. of its repetitive DNA sequences.
D. of its ability to use restriction enzymes.
B
Long interspersed elements (LINES) are a type of
A. pseudogene.
B. proteome.
C. exon.
D. intron.
E. transposon.
E
The sequences for your research have been collected and there seem to be a few variants in the sequence structures called SNPs. In order for these SNPs to be classified as a polymorphism, they must be found in
A. every draft sequence of the species being
D
Non-coding DNA regions within a gene are referred to as
A. introns.
B. exons.
C. templates.
D. transposons.
E. pseudogenes.
A
When looking at microarray data verses phenotypic behaviors in a model organism, you notice that certain genes seem to have lost their function. Therefore you decide to classify them as
A. nonfunctioning introns.
B. inactivated exons.
C. templates.
D. tra
E
A large portion (45%) of the human genome is composed of
A. introns.
B. exons.
C. templates.
D. transposons.
E. pseudogenes.
D
Some regions of chromosomes remain highly condensed, tightly coiled, and untranscribed throughout the cell cycle. These regions are referred to as
A. transposable elements.
B. single sequence repeats.
C. non-coding DNA.
D. short interspersed elements.
E.
E
Linkage disequilibrium is the tendency for
A. be totally randomized during meiosis.
B. be non-randomly associated during meiosis.
C. to be rearranged during meiosis because of crossing over.
D. link together within certain blocks along the chromosome.
E.
B
Microarrays are created by robotically placing DNA on to a microscope slide and probing with
A. RNA from the tissue of interest.
B. another DNA from the tissue of interest.
C. SNPs from the tissue of interest.
D. STSs from the tissue of interest.
E. clone
A
A private company has been hired by the Parliament of Iceland to create a database from pooled medical, genetic, and genealogical information. The primary issues the company might face are
A. ownership and privacy violations.
B. financial gain violations.
A
When analyzing DNA using restriction enzymes, you notice that some of your fragments are shorter than others. This is best explained by
A. variations in landmarks of DNA sequencing.
B. differences in contig fragments.
C. various single length polymorphism
D
To avoid confusion and facilitate ease of data interpretation, researchers working on cloned DNA from the same species use
A. restriction fragment length polymorphisms.
B. shotgun sequencing.
C. sequenced-tagged sites.
D. clone by clone sequencing.
E. con
C
. The sequencing method that cuts DNA segments into fragments, arranges those fragments based on overlapping nucleotide sequences, and then clones these fragments is called
A. shotgun sequencing.
B. clone-by-clone sequencing.
C. RFLP sequencing.
D. consen
B
The sequencing method that cuts the DNA of an entire chromosome into small fragments and then clones these fragments is called
A. shotgun sequencing.
B. clone-by-clone sequencing.
C. RFLP sequencing.
D. consensus sequencing.
A
When comparing the genomes of prokaryotes verse eukaryotes, it can be accurately stated that
A. eukaryotic genomes are larger than prokaryotic genomes.
B. eukaryotic genomes are smaller than prokaryotic genomes.
C. the size of the organism determines the
A
The majority of DNA in a human can be described as
A. composed of short interspersed elements.
B. non-coding.
C. simple sequence repeats.
D. segmental duplications.
E. structural.
B
Rice and its grain relatives, maize, barley, and wheat, diverged from a common ancestor 50 million years ago. However, the chromosomes of these plants demonstrate extensive conserved arrangements of segments. This phenomenon is called
A. linkage disequili
D
Groups of related, but distinctly different genes that appear to have arisen from a single ancestral gene are referred to as
A. segmental duplications.
B. pseudogenes.
C. tandem clusters.
D. multigene families.
E. expressed sequences.
D
. Identical copies of genes that can be transcribed simultaneously are called
A. segmental duplications.
B. pseudogenes.
C. tandem clusters.
D. multigene families.
E. expressed sequences
C
Recombination frequency between genes can be used to generate a
A. genetic map.
B. physical map.
C. restriction map.
D. haplotype map.
A
Your research project involves the characterization of a novel protein. To learn more about its function, you perform a yeast two-hybrid screen to identify potential interacting proteins. In the first screening attempt, one clone is isolated and sent to b
A
Given an ideal sequencing reaction of approximately 500 successive nucleotides (excluding overlap), how many sequencing reactions would be needed to determine the complete human genome?
A. 3.2 billion
B. 12.5 million
C. 12.8 million
D. 6.4 million
D
Your research group has recently determined the complete genomic sequence of the organism Examus biologisium. You instruct your group to begin sequence annotation, which involves
A. shotgun cloning.
B. the alignment of contigs.
C. the identification of op
C
The reason segmental duplications pose a logistical challenge in the proper alignment of DNA sequences is that they
A. are inherently repetitive.
B. contain large numbers of LINEs, which interfere with sequence annotation.
C. interfere with BLAST analysis
A
You have finished collecting a set of human DNA sequences, and wish to add this to the
catalog of variations of the same gene. The proper placement of such data would be in a
A. haplotype map.
B. restriction map.
C. genomic map.
D. SNP map.
A
The best technique for detecting chromosomal abnormalities is
A. EST
B. FISH
C. STS
D. SNP
B
The organism with the largest relative genome size is
A. rice.
B. human.
C. fruit fly.
D. yeast.
B
When comparing the actual number of genes, the organism with the highest number is
A. rice.
B. human.
C. fruit fly.
D. yeast.
A
45. Traditionally, toxicology studies have involved numerous bioassays on rodents. However, a
more reliable and reproducible approach to study the genomewide effects of a toxin is
A. a protein microarray.
B. functional genomics.
C. a yeast twohybrid scree
D
In the early 1980s, clones encoding highly related forms of actin were isolated from human
cDNA. Given the information that the restriction enzyme maps of the coding regions were dissimilar, and each clone contained sufficient coding regions to encode all
D
A pharmaceutical company is seeking a new drug to help combat a rare disease. In order to facilitate identification of new drug targets, their efforts would be best directed toward
A. employing protein microarray technology to evaluate the binding of drug
A
What is the most significant impact of the rice genome project?
A. The ability to accelerate genome data development for similar cereal crops.
B. The rice genome was found to be even larger than that of humans.
C. The development of Golden Rice, already e
A
After years of work, a researcher identifies a novel protein that binds to serotonin receptors in the mouse brain. The most appropriate conclusion about the gene patenting necessary would be
A. The researcher has clearly defined the function of the gene.
D
The best description of how the study of genomics is expected to influence health care is
A. to provide insight into the relationship between genes and the environment, enabling us to learn more about the causes and affects of various diseases and infecti
A