What is aspirin?
irrev Cox-1 and cox-2 inhibition
Why is aspirin anti-inflammatory while acetaminophen is not?
acetaminophen works in the CNS and is inactivated by peroxidases of inflammation
What is diflunisal?
competitive Cox -
What is acetaminophen?
rev cox -, CNS>periph
What drug causes Reye's syndrome?
aspirin
What is indomethacin?
Cox - (also - PMNs)
What is suldinac?
cox -
What is etodolac?
Cox - (2>1?, non-sel in book)
What are mefenamic acid and meclofenamate Na?
PG -
What is ketorolac?
cox -
What is difclofenac?
cox -
What drug causes diarrhea w/ steatorrhea and rare hemolytic anemia?
mefenamic acid
What drug causes frontal headache and CNS effect?
indomethacin
What drug decreases familial intestinal polyposis and is used in rheumatic disease?
suldinac
What rug is used to treat post-op nausea?
diclofenac
What do cox - do?
anti-pyretic, analgesia
In addition to anti-inflammation, antipyretic and analgesia what does aspirin do?
antiplatelet (-TXA, PGI)
Which drug closes PDA?
indomethacin
What is a primary side effect of NSAIDs?
GI ulcer and bleeding
What is ibuprofen?
rev non-sel cox -
Where do the arachidonic acid precursors of PGs/TX/LTs come from?
phospholipids after phospholipase A2 action, under influence of TNF-a
What drugs are sel Cox-2 inhibitors?
celecoxib, meloxicam
What drug treat dysmenorrhea?
mefenamic acid, meclofenamate
What is naproxen?
cox -
What is piroxicam?
cox - (and PMN migration -, decrease free rads)