Diuretics

What is acetazolamide

CA inhibitor

Where do CA inhibitors act?

proximal tubule

Where do osmotic diuretics act?

proximal tubule and descending limb

Where do loop diuretics act?

ascending limb

Where do thiazide diuretics act?

distal tubule

Where do K sparing diuretics act?

collecting duct

What is conivaptan?

ADH inhibitor

Which receptors does conivaptan act on?

V1a, v2

What is mannitol?

osmotic diuretic

What is amiloride?

K sparing

What is triamterene?

K sparing

What is spironolactone?

K sparing

What is eplerenone?

K sparing

What is indapamide?

thiazide

What is metolazone?

thiazide

What is chlorthalidone?

thiazide

What is furosemide?

loop

What is bumetanide?

loop

What is ethacrynic acid?

loop

What is acetazolamide's effect on HCO3?

increase in lumen (alkalinize urine)

What is acetazolamide's effect on Na?

inhibit Na/H exchange

What is acetazolamide used for?

alkalosis

What causes type 2 RTA?

acetazolamide

What causes kidney stones?

triamterene, acetazolamide

What causes uric acid retention?

loop, thiazides

What is ototoxic?

loop

What causes low magnesium?

loop, thiazide

What causes hyperglycemia and hyperlipidemia?

thiazides

What causes hypokalemic metabolic alkalosis?

loop, thiazide

What causes hyperchloremic metabolic acidosis?

k sparing

What causes gynecomastia?

spironolactone

What causes hyponatremia?

osmotic, thiazides, loop

What is used to treat cerebral edema?

osmotic

What is used to treat hyperaldosteronism?

K sparing

What is used to treat hypercalciuria?

thiazides

What is used to treat nephrogenic DI?

thiazides

What is used to treat hypercalcemia?

loop

What inhibits Na/k/2Cl cotransport?

loop

What inhibits Na/Cl cotransport?

thiazides

What acts as an aldo receptor block and Na channel inhibitor?

K sparing

What causes decreased ca secretion?

thiazides

What causes increased magnesium secretion?

thiazides, loop

What causes decreased bicarb secretion?

thiazides, loop

What causes decreased urate secretion?

thiazides, loop