Pharm Ch. 8

What is the mechanism of action of nystatin?

Increasing membrane permeability

Which is True and or which is false?
Candida albicans is a frequent inhabitant of the oral cavity, and it usually causes fungal infections.

The first part is true; the second part is false

What are special considerations that should be made when prescribing Nystatin?

A. Patients with xerostomia may have problems with the pastille dose form.
B.The high sugar content of the aqueous suspension must be taken into account with diabetics during meal planning and insulin use.
D. Vaginal tablets can be used as an oral lozenge

The most frequent adverse drug effect of the imidazoles involves which body system?

Gastrointestinal system

What is the most serious adverse drug effect of ketoconazole?

Hepatotoxicity

What special considerations should be made for patients taking ketoconazole?

A. Pregnant women should be advised not to take this medication.
B. Ketoconazole may decrease the effects of oral contraceptives.
C. Patients with achlorhydria should take ketoconazole with hydrochloride acid.
D. Medications that interfere with the normal

Which is True and or which is false?
Ketoconazole is indicated in the treatment and management of mucocutaneous and oropharyngeal candidiasis. Because of its lack of serious adverse reactions, systemic use of this drug is preferred to topical antifungal a

The first part is true; the second part is false

__________ is used to treat oropharyngeal and esophageal candidiasis and serious systemic candidal infection in immunocompromised patients or for treatment of candidal infections that do not response to other agents.

Fluconazole

This antifungal agent is produced by Streptomyces nodosus and it has so many potentially serious adverse effects that it is only administered parenterally when serious systemic fungal infections have failed to respond to other agents.

Amphotericin

Which is True and or which is false?
Antiviral work with a similar mechanism of action as antibacterial drugs because viruses are obligate intracellular organisms that require the host cell to be damaged to kill the virus.

The first part is false and second is true

Which of the following is the mechanism of action for the antiviral agent acyclovir?

Nucleic acid analogues that inhibit deoxyribonucleic acid synthesis

What are the indications for the use of acyclovir?

Herpes simplex 1 and 2 viruses, Varicella-zoster virus, Epstein-Barr virus, and Cytomegalovirus

What is the action of acyclovir?

Produces a shortened duration of the infection

What medications are indicated for the treatment of oral herpes simplex

Acyclovir, Penciclovir, Docosanol, and Famciclovir

What is Zidovudine prescribed for?

Zidovudine is a thymidine analogue and is used in treatment of HIV by inhibiting synthesis of the virus.

Nystatin, miconazole, clotrimazole, and ketoconazole are given to treat what condition?

Candida albicans

Which categories of medications are used to treat human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)?

Nonnucleoside reverse transcriptase inhibitors and Protease inhibitors

What are Imidazoles prescribed for?

Fungal infections

Amantadine (Symmetrel) is used for what indications?

A. Prevention of influenza A
B. Antiparkinson action
C. Reduces symptoms of influenza A

Alpha-, beta-, and gamma-interferon have received Food and Drug Administration (FDA) approval for what of the following indications?

A. Multiple sclerosis
B. Hepatitis B
D. Hepatitis C
E. Hairy cell leukemia

Nystatin is available for treatment of oral candidiasis in the form of an aqueous suspension and oral pastilles. What special considerations should be made with these dose forms?

B. Diabetics using the suspension must take the sugar content into account (2.5 grams sucrose per teaspoon) when planning their meals and insulin use.
C. For infants and small children with thrush, 2.5 ml is placed in each side of the mouth and rubbed int

The mechanism of action of the imidazoles in treatment of fungal infections is:

Alteration of cell membrane permeability and interference with intracellular enzymes

The most common adverse reactions associated with the antifungal agent ketoconazole is:

Gastrointestinal distress, nausea, and vomiting

The indications for griseofulvin include what conditions?

Infections of the skin, hair, and nails