THERAPEUTIC
antihyperlipidemic
PHARMACOLOGIC
statin
TREATS
blocks synthesis of cholesterol in the liver,
decrease LDL, decrease VLDL, decrease cholesterol, idecrease triglycerides
MECHANISM OF ACTION
blocks HMG-CoA reductase in the liver
ROUTE
PO
METABOLISM
hepatic, extensive metabolites
EXCRETION
biliary
ADVERSE EFFECTS
headache
GI - ABD cramping, diarrhea, constipation
life threatening - rhabdomyolyis - renal failure
s/s muscle pain, BLE weakness, fever, fatigue
BLACK BOX
n/a
CONTRAINDICATIONS & PRECAUTIONS
liver dz - increase LFTs (AST/ALT)
pregnancy (birth defects)/lactation
DRUG INTERACTIONS
increase digoxin lvls
decrease metabolism = increase risk for toxicity, increase risk of rhabdomyoIysis
erythromycin - increase Lipitor lvls
St. John's wort - decrease efficacy
grapefruit juice - increase toxicity
OVERDOSE TX
No specific tx
NURSING RESP / PT TEACHING
monitor LFTs (AST/ALT)
take at night when increase biosynthesis of cholesterol
monitor for s/s of rhabdomyolysis
diet, exercise, fish oil, flaxseed
no ETOH, quit smoking
no pregnancy/lactation