Insulin

Human insulin lispro (Humalog) - type

rapid acting

(Humalog) - type

rapid acting

rapid acting - onset

5-15 minutes

rapid acting - peak

30-60 min

(Humalog) - peak

30-60 min

rapid acting - duration

3-4 hours

(Humalog) insulin lispro
- duration

3-4 hours

Rapid acting nursing implications (Lispro and Aspart)

give within 15 min of a meal

Aspart (Novolog) - type

rapid acting

Regular insulin (human) (Humulin R, Novolin R) - type

short acting

(Humulin R, Novolin R) - type

short acting

short acting - onset

30-60 min

short acting - peak

2-5 hr

short acting- duration

4-8 hr

short acting nursing implications

regular insulin may be given IV

Intermediate acting implications

do not give IV
mixtures are NPH 30 and regular 70

combination

NPH 30, regular 70

NPH

Isophane insulin (humulin N, Novolin N) - intermediate

Isophane insulin (Humulin N, Novolin N) - type

intermediate acting

(Humulin N, Novolin N) - type

intermediate acting

intermediate acting - onset

1-2 hr

intermediate acting - peak

4-12 hr

intermediate acting - duration

18-24 hr

long acting nursing implications

not for IV
give once a day SUBQ at nighttime
acts as basal insulin
do not shake or mix

Glargine (Lantus) - type

long acting

Glargine (Lantus) - onset

1 hr

Glargine (Lantus) - peak

No peak

Glargine (Lantus) - duration

24 hr

Detemir (Levemir) - type

long acting

long acting- peak

No peak

Detemir (Levemir) - onset

3-4 hr

long acting- duration

24 hr

Humalog 75/25
Novolog 70/30
Humalog 50/50

premixes

Premix onset

5-30 min

premix peak

varies 1-4 hours

premix duration

10-16 hours

Humulin 70/30
isophane NPH 70%/regular 30%
(onset)

30 min

Humulin 70/30
(peak)

4-8 hours

Humulin 70/30
(duration)

22-24 hours

Humulin 50/50
isophane NPH 70%/regular 30%
(onset)

30 min

Humulin 50/50
isophane NPH 70%/regular 30%
(peak)

4-8 hr

Humulin 50/50
isophane NPH 70%/regular 30%
(duration)

24 hr

Humalog Mix 75/25
onset

5-15 min

Humalog Mix 75/25
peak

30 min-6 hr

Humalog Mix 75/25
duration

20-24