Biochem Chapter 26

Glycerol and fatty acids make ________, the precursor to: .

-TAGS and phospholipids

what two moieties come together to make phosphatidate?

fatty acid with high energy thioester (attached to CoA) and glycerol 3- phosphate

Acetyl-CoA is made into _________ then into ________ then _______.

HMG-CoA, mevalonate, activated isoprene (IPP)

All lipids in biology are made from ________.

acetyl CoA

what is the enzyme is involved in the commited step of the mevalonate pathway?
what does it harness power from?
What does it produce?

-HMG-CoA reducatase

IPP can be made into any isoprenoid, including ______ that is made into lanosterol (dont worry about this name) that is made into ________.

squalene, cholesterol.

What is the most abundant and most important steroid?


why is cholesterol so important? where is most of it found?

Most of it is found in the membrane of cells.. It regulates the fluidity and rigidity of the membrane. With out it, the cell would die.

What are Plasma lipoproteins? (as opposed to lipidated lipoproteins)

very large non-covalent complexes of protein and lipids that serve for lipid delivery.

________ lipoprotein is tightly regulated whereas _________ lipoprotein can accumulate in the blood and lead to plaque and cardiovascular disease.

High-density, low-density

The statin drugs are inhibitors of ____________-, the committed step enzyme in the mevalonate metabolism pathway (decreasing cholesterol biosynthesis).

HMG-CoA reductase

The statin drugs are inhibitors of _________. , the committed step enzyme in the_______ metabolism pathway. This inhibits the formation of ______.

HMG-CoA reductase, mevalonate, cholesterol

Cholesterol is excreted as ______ ______�which are normally largely reabsorbed, which resorption can be decreased by _______ drugs.

bile salts, sequestrant

_________ is the precursor of all other bioactive steroids and vitamin D (as well as the bile salts).