SLE is an ______ disease.
SLE is characterized by the presence of _______.
______ are the cause of the pathogenesis of disease in SLE.
T/F: The treatment approach for SLE is individualized for each patient?
What is the main hallmark of SLE?
Positive Anti-nuclear antibodies (ANA)
Which antigens are implicated in SLE?
- Sm antigen
Which antigen associated with SLE can be due to drug-induced LE?
Diagnosis of SLE must contain at least 4 of the following:
- Malar rash
- Discoid rash
- Positive ANA
- Oral ulcers
- Kidney disease
- Neurologic disorder
- Hematologic disorder
- Positive antibodies
What are some GI manifestations of SLE?
- Abdominal pain
- Abnormal liver enzymes
Which drugs have a definite drug association with SLE?
What are the main groups of drugs used in the treatment of SLE?
- Immunoglobular antimetabolites
- Biologic agents
Which drug is the first line agent for arthritis, musculoskeletal pain, fever and serositis?
What is the general MOA of NSAIDs?
What are some side effects of NSAIDs?
- GI bleeding
- Aseptic meningitis
- Complications in detecting lupus
Relatively low doses of ______ are used to treat arthritis, cutaneous manifestations and serositis?
Relatively high doses of cortiocosteroids are used to treat ______, _____, _____, and _____ in SLE.
What is the mainstay in therapy during pregnancy for SLE?
What are some side effects of cortiocosteroids?
Which antimalarial drug is used in the treatment of SLE?
Hydroxychlorquine is used to prevent ______ in SLE.
What is the MOA of hydroxychloroquine?
- Increases the pH of lysosomes from 4 to 6
- Decreases immune cell functioning
- Inhibits MHCII association with self-proteins
What are some side effects of antimalarials in SLE?
- Antithrombotic effects
- Lipid lowering effects
- Macular damage
Immunosuppressive act as anti-________.
Mycophenolate mofetil (MMP) is a ______ to improve oral bioavailability.
Mycophenolate is marketed as ______.
Mycophenolate sodium is marketed as _____.
What is the MOA of mycophenolic acid?
Reversibly inhibits inosine monophosphate dehydrogenase
Inosine monophosphate dehydrogenase controls the synthesis of ____ in the de novo pathway of ______ biosynthesis.
_____, _____, and _____ are immunosuppressants that inhibits T-cell and B-cell proliferation.
Cyclophosphamide is an _______ agent.
_______ interferes with DNA replication by intra-strand DNA cross-links.
_______ is commonly used to treat severe organ system disease and nephritis in SLE.
What are some side effects of cyclophosphamide?
- Passes through placenta and into breast milk
- Hemorrhagic cystitis
- Bladder/gonadal toxicity
Which immunosuppressant is preferred in pregnancy?
Which drug can be used to prevent bladder/gonadal toxicity associated with cyclophosphamide?
(2-mercaptoethane sulfonate Na)
What immunomodulator antimetabolies are used in the treatment of SLE?
Immunomodulator antimetabolies most strongly affect the proliferation of ____ and ____ cells.
Azathiopurine is a prodrug that is metabolized into _______.
What are the uses of immunomodulator antimetabolites in SLE?
Useful in non-renal manifestations of SLE
What are some side effects of the immunomodulator antimetabolites?
- Bone marrow toxicity
- GI toxicity
- Monitor for signs of infection, sore throat
- Liver/pancreas toxicity
Which biologic agents are used in the treatment of SLE?
Belimumab is an anti- _______ agent.
Rituximab is an anti- ______ agent.
Tocilizumab is an anti-______ agent.
Infliximab is an anti-_____ agent.