Miscellaneous Antifungal Questions

What type of heterotoph derives nourishment from dead organic matter?

Saprophytic heterotroph (a parasitic heterotroph derives its nourishment from a living host)

Name the 2 distinct classes of Azoles

Imidazoles and Triazoles

Ketoconazole, Clotrimazole, and miconazole are mainly used to treat what?

Vaginal and epidermal candidiasis (although fluconazole (Diflucan) is often first line treatment for candidiasis)

What is the black box warning for oral ketoconazole for?


What is the DOC for many susceptible fungal infections including invasive/noninvasive candidiasis and cryptococcal disease?

Fluconazole (Diflucan)

What is the DOC for dimorphic fungal infections such as histoplasmosis?


Due to a black box warning, what type of patients should avoid taking itraconazole due to inotropic effects?

patients with systolic heart failure

What antifungal medication is given prophylactically for fungal infections in neutropenic patients?

Posaconazole (also used for treatment of oropharyngeal candidiasis)

What is the DOC of cryptococcal meningitis (along with Flucytosin) and is also indicated for severe systemic infections?

Amphotericin B

What is the DOC for onychomycosis (toe fungus)?

Terbinafine (Lamisil AT)

Caspofungin, Micafangin, and Anidulafungin are all examples of what type of antifungals? (Hint: this class of anti-fungals are also known as glucan synthesis inhibitors)


What is the most common use for Griseofulvin (Grifulvin V)?

Tx of tinea capitis