PDGFB
Function: Platelet-derived growth factor
Mechanism: Overexpression, autocrine loop
Associated tumor: Astrocytoma
ERBB2 (HER2/neu)
Function: Epidermal growth factor receptor
Mechanism: Amplification
Associated tumors: subset of breast carcinomas
RET
Function: Neural growth factor receptor
Mechanism: Point mutation
Associated tumor: MEN 2A, MEN 2B, sporadic medullary carcinoma of the thyroid
KIT
Function: Stem cell growth factor receptor
Mechanism: Point mutation
Associated tumor: GI stromal tumor
RAS gene family
Function: GTP-binding protein
Mechanism: Point Mutation
Associated tumor: Carcinomas, melanoma, lymphoma
ABL
Function: Tyrosine kinase
Mechanism: t(9;22) with BCR
Associated tumor: CML and some types of ALL
c-MYC
Function: Transcription factor
Mechanism: t(8;14) involving IgH
Associated tumor: Burkitt lymphoma
N-MYC
Function: Transcription factor
Mechanism: Amplification
Associated tumor: Neuroblastoma
L-MYC
Function: Transcription factor
Mechanism: Amplification
Associated tumor: Lung carcinoma (small cell)
CCND1 (cyclin D1)
Function: Cyclin
Mechanism: t(11;14) involving IgH
Associated tumor: Mantle cell lymphoma
CDK4
Function: Cyclin-dependent kinase
Mechanism: Amplification
Associated tumor: Melanoma