Mosby's NBDE Part II: Pharmacology

local anesthetic

Efficacy

Affinity

Higher

Potency

EC50

Agonists

Antagonists

Therapeutic index

Prodrug

Phase 1

Phase 2

Liver

Dose

Clearance

Zero

First

Cytochrome P-450

Side effect

Idiosyncratic reaction

Aspirin

Aspirin

Acetaminophen (Tylenol)

Cytochrome P-450

Phase I

Phase II

Phase III

Phase IV

A, B, C, D, X

Pure Food and Drug Act

Food, Drug, and Cosmetic Act

ACh

NE