Ch. 33 - 1

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polycystic kidney disease (PKD)

dom or rec; formation of fluid filled sacs w/in renal tubules of nephron; singular or multiple; microscopic or grape size;

autosomal dominant PKD

PKD; most common cystic disease; 100-1000 large fluid filled cysts forming in kidneys; 2 types

type I autosomal dominant PKD

PKD; most common autosomal dom PKD; due to mutation of PKD1; progresses faster

type II autosomal dominant PKD

PKD; due to PKD2 and progresses slower

polycystin proteins

found in cilia of epithelial lining of renal tubules that monitor flow thru tubules to trigger cell division, differentiation, and apoptosis of tubular cells

autosomal recessive PKD

PKD; leads to dilation of collecting ducts in both cortical and medullary nephrons; present in infants w/in first few weeks of life; masses in kidneys

hydronephrosis

urine filled dilation of renal pelvis and calyces that causes atrophy of kidneys from obstruction

renal calculi (kidney stones)

most common type of upper urinary tract obstruction that occur mostly in kidneys; supersaturated urine - precipitate

UTI

common bacterial infection that may be in lower UT or upper UT

glomerular disorders

affect glomeruli ability to form filtrate

glomerulonephritis

inflammation of the glomeruli of the kidney; 2nd leading cause of kidney failure

acute nephritic syndrome

acute glomerular inflammation that damages glomerular wall from infection or associated with lupus;

Acute Postinfectious Glomerulonephritis

acute nephritic syndrome; after infection with strep, straph, chicken pox, mumps; formation of immune complexes that collect in glomeruli