mens health

testosterone is made by the ___ of the testes
a. schiffers
b. leydig
c. sertoli
d. b and c

b

testosterone is produced by the
a. kidney
b. testes
c. adrenal gland
d. b and c

d
mainly testes

testosterone is stimulated by
a. FSH
b. LH
c. ACTH
d. all of the above

d
ACTH regulates adrenal secretion

the prostate, hair follicles and seminal vesicles respond more to
a. testosterone
b. DHT

b

testosterone accelerates
a. skeletal growth
b. muscular growth
c. epiphyseal plate closure
d. all of the above

d

testosterone will have the least effect in
a. young males
b. young females
c. healthy adult male

c
can be dramatic in young males/females

testosterone therapy has FDA approval for treatment of
a. hypogonadism
b. replacement therapy
c. replacement therapy in women
d. a and b

a

oxandrolone is used to treat
a. hypogonadism
b. replacement hormones therapy in women
c. cachexia
d. delayed puberty

c

oxandrolone has a black box warning for
a. virilization
b. hepatitis
c. increase risk of atherosclerosis
d. b and c

d

androgens given to children may ___; therefore ___ is recommended
a. cause hepatotoxicity
b. cause premature epiphyseal plate closure
c. monitor liver labs
d. xray every 6 months

b, d
and
a, c (mostly in adult though)

___ are most closely associated with hepatotoxicity
a. testosterone
b. testosterone esters
c. 17-alpha-alkylated compounds

c

androgens may ___ LDL and ___ HDL
a. decrease
b. increase

b, a

treatment with androgens may cause all except
a. edema
b. prostate cancer
c. thromboembolic events
d. atherosclerosis

b
can promote growth, but won't cause

hypogonadism is treated with ___ and ___
a. oral fluoxymesterone
b. parenteral testosterone esters
c. oxandrolone
d. PO testosterone cypionate

a, b
PO 17-alpha-alkylated, parenteral esters
17 alpha alkylated NOT first line due to hepatotoxicity

when applying testosterone underarm, deodorant should be applied
a. first
b. second

a

testosterone pellets are indicated for
a. hypogonadism
b. delayed puberty
c. hormone replacement
d. a and b

d

IM testosterone
a. is indicated for replacement therapy
b. provides a controlled testosterone release
c. has variable testosterone release
d. has the least amount of side effects

c

androgens are a schedule
a. I
b. II
c. III
d. IV

c

androgens are contraindicated for all except
a. athletic performance
b. liver disease
c. pregnancy
d. prostate/breast cancer

b

PDE-5 inhibitors affect ED by ___ levels of cGMP
a. increasing
b. decreasing

a

in the absence of sexual stimuli, sildenafil will
a. cause erection
b. decrease arousal
c. do nothing

c

which of the following is not an adverse effect of sildenafil
a. priapism
b. hypertension
c. optic neuropathy
d. hearing loss
e. sleep apnea

b
causes hypotension

___ is contraindicated with sildenafil
a. apha blockers
b. inhibitors of cyp3a4
c. nitrates
d. cephalosporins

c
alpha blockers and cyp3a4 use with caution

if taking nitrates, sildenafil should be dosed at least ___ apart
a. 6 hours
b. 15 hours
c. 24 hours
d. 3 days

c

postural hypotension may occur with sildenafil is used with
a. alpha blockers
b. beta blockers
c. cyp3a4 drugs
d. all of the above

a

which of the following may prolong the QT
a. vardenafil
b. sildenafil
c. tadalafil
d. avanafil

a

which of the following has the most rapid onset
a. vardenafil
b. sildenafil
c. tadalafil
d. avanafil

d

which of the following has the longest duration and may be dosed daily, allowing for spontaneity
a. vardenafil
b. sildenafil
c. tadalafil
d. avanafil

c

alprostadil is administered
a. intraurethral
b. intracavernous
c. PO
d. a and b

d

overgrowth of epithelial cells causes ___ where overgrowth of smooth muscle causes
a. mechanical obstruction
b. dynamic obstruction

a, b

5 alpha reductase inhibitors are mostly used to treat men with ___ and ___ prostates
a. dynamic obstruction
b. mechanical obstruction
c. larger
d. smaller

b, c

___ are preferred for men with smaller prostates and dynamic obstruction
a. 5 alpha reductase inhibitors
b. alpha blockers

b

finasteride is a
a. 5 alpha reductase inhibitors
b. alpha blockers

a

5 alpha reductase
a. converts testosterone to estrogen
b. prevents conversion of testosterone to DHT
c. converts testosterone to DHT
d. converts DHT to testosterone

c

finasteride protects against ___ grade prostatic cancer
a. low
b. high

a
does not protect against high grade-may cuase high grade cancer

___ and ___are category X and should be avoided in women who are pregnant
a. dutasteride
b. silodosin
c. alfuzosin
d. finasteride

a, d

___ causes PSA levels to drop
a. silodosin
b. alfuzosin
c. teraqzosin
d. finasteride

d

BPH treatment
a. is lifelong
b. is d/c'ed once PSA levels fall
c. is continued for 1 year

a

___ has a longer half life
a. finasteride
b. dutasteride

b
also, more complete DHT reduction

5 alpha reductase inhibitors cause ___ which reduces ___
a. relaxes smooth muscle
b. reduces prostate size
c. reduces mechanical obstruction
d. reduces dynamic obstruction

b, c

alpha blockers cause ___ which reduces ___
a. relaxes smooth muscle
b. reduces prostate size
c. reduces mechanical obstruction
d. reduces dynamic obstruction

a, d

which of the following may be used to relax smooth muscle in the bladder
a. tadalafil
b. dutasteride
c. alfuzosin
d. finasteride

c

alpha blockers ___ size of the prostate
a. increase
b. decrease
c. do not change

c

alpha blockers are used mostly to ___
a. decrease prostate size
b. relax smooth muscle of the bladder

b

alpha blockers produce BPH results
a. slowly
b. rapidly

b
5 apha reductase slow

which of the following is/are selective alpha blockers
a. silodosin
b. tamsulosin
c. alfuzosin
d. a and b

d
alfuzosin, terazosin, doxazosin are nonselective-use for htn and bph

alpha blockers ___ PSA levels
a. increase
b. decrease
c. neither

c

men considering cataract surgery should avoid
a. 5 alpha reductase inhibitors
b. alpha blockers
c. pde-5 inhibitors

b

alpha blockers should be used in caution with
a. nitrates
b. PDE-5 inhibitors
c. antihypertensives
d. all of the above

d

___ may treat both BPH and ED
a. sildenafil
b. tadalafil
c. alfuzosin
d. finasteride

b

a man taking an antidysrhythmic should avoid
a. tadanafil
b. finasteride
c. vardenafil
d. alfuzosin

c