Addison's disease
Hyperpigmentation of oral mucosa as well as sun exposed skin, sites of trauma and creases of palms soles
aquired immune deficiency
HPV, herpes implex virus, varicella zoster, cytomegalovirus, bacterial abscesses, etc
Chagas' Disease (American Trypanosomiasis)
unilateral conjunctivitis and lid edema associated with preauricular lymphadenopathy
Chronic Renal disease
Pallor, xerosis, pruritus, hyperpigmentation, uremic frost, metastatic calcification in the skin, calciphylaxis, "half and half" nails
CREST syndrome
Calcinosis, Raynaud phenomenon, sclerodactyly, matted telangiectsaias of face and palms
Chron's disease
erythema nodosum, pyoderma gangrenosum, enterocutaneous fistulas, aphtous ulcers
Cushing's disease
Striae, atrophy, purpura, ecchymoses, telangectasias, acne, buffalo hump
Dermatomyosistis
Violaceous erythema as macules, patches, or papules in periocular region, interphlangeal joints, and on upper back and shoulders
Diabetes
pruritis, candidiasis, neuropathic ulcers, necrobiosis lipoidica, eruptive xanthomas
disseminated intravascular coagulation
purpura, petechiae, hemorrhagic bullage, induration, necrosis
Gonococccemia
purple to grey macules, papules, or hemorrhagic pustules over acral and pariarticular surfaces
hemochomatosis
skin bronzing and hyperpigmentation
hypothyroidism
Dry, rough, and pale skin; coarse and brittle hair; myxedema; alopecia (lateral third of the eyebrows to diffuse); skin cool to touch; thin and brittle nails
Hyperthyroidism
warm, moist, soft and velvety skin, thin and fine hair, alopecia, vitiligo,
infective endocarditis
Janeway lesions, Osler nodes, splinter hemorrhages, petechiae
Kawasaki disease
Mucosal erythema (lips, tongue, and pharynx), strawberry tongue, cherry red lips, polymorphous rash (primarily on trunk), erythema of palms and soles with later desquamation of fingertips
Liver disease
jaundice, spider angiomas, palmar erythema, terry nails, purpura
leukemia/lymphoma
Pallor, exfoliative erythroderma, nodules, petechiae, ecchymoses, pruritus, vasculitis, pyoderma gangrenosum, bullous diseases
Medium vessel vasculitides
livedo racemosa, purpuric nodules, ulcers
neurofibromatoses 1
neurofibromas, cafe-au-lait spots, freckling in the axillae
pancreatitis
bruising and induration in the CVA
pancreatic carcinoma
panniculitis, migratory thrombophlebitis
Porphyria cutanea tarda
photossensitivity with bullae and skin fragility on dorsal hands and forearms
Pyoderma gangrenosum
painful pustule quickly progressing to ragged ulcer with sharply marginated violaceous border and undermined edges
Rocky Mountain Spotted Fever
pink or reddish papules progressing to purpuric papules, starts on wrists and ankles and spreads to the palms, soles and then to trunk and face
Sarcoidosis
Red-brown plaques, often annular, typically involving the head and neck and especially the nose and ears; may show apple jelly color with dermoscopy
SLE
malar erythema, relative sparing of nasolabial folds