Human Genetics Chapter 9

ribose

a 5-carbon sugar in RNA

deoxyribose

5-carbon sugar in DNA

adenine

one of two purine nitrogenous bases in DNA and RNA; pairs with T

thymine

one of two pyrimidine bases in DNA; pairs with A

guanine

one of the two purine nitrogenous bases in DNA and RNA; pairs with C

cytosine

one of the two pyrimidine nitrogenous bases in DNA and RNA; pairs with G

gene

a sequence of DNA that instructs a cell to produce a particular protein

nucleotide

the building block of a nucleic acid, consisting of a phosphate group, a nitrogenous base, and a 5-carbon sugar

purine

a DNA base with a two-ring structure; adenine and guanine

pyrimidine

a DNA base with a single-ring structure; cytosine, thymine, and uracil

sugar-phosphate backbone

the "rails" of a DNA double helix, consisting of alternating deoxyribose and phosphate groups, oriented opposite one another

antiparallelism

the head-to-tail position of the entwined chains of the DNA double helix

complementary base pairs

the pairs of DNA bases that hydrogen bond; adenine bonds to thymine and guanine to cytosine

histone

a type of protein around which DNA entwines

nucleosome

a unit of chromatin structure

chromatin

DNA and its associated proteins

semiconservative

The route to DNA replication is called ___ because each new DNA double helix conserves half of the original.

replication fork

locally opened portion of a replicating DNA double helix

DNA polymerase

an enzyme that adds new bases to replicating DNA and corrects mismatched base pairs

ligase

an enzyme that catalyzes the formation of covalent bonds in the sugar-phosphate backbone of a nucleic acid

carbons in the sugar are numbered

The antiparallel nature of the DNA double helix becomes apparent when what are numbered?

conservative

Possible DNA replication type with one double helix specifying creation of a second double helix.

dispersive

Possible DNA replication type with a double helix shattering into pieces that would join newly synthesized DNA pieces to form two molecules.

S phase

DNA replication occurs during what phase of the cell cycle?

primase

What is the enzyme called that attracts complimentary RNA molecules to build a short piece of RNA during DNA replication.

RNA primer

The short piece of RNA called that is built at the start of each segment of DNA to be replicated.

helicase

What is the enzyme called that unwinds and hold apart replicating DNA enabling other enzymes to guide the assembly of a new DNA strand?

binding proteins

What stabilizes the separated strands of DNA during replication?

Identification of nuclein

Experiment: Discover of an acidic substance that includes nitrogen and phosphorus on dirty bandages

Complimentary base pairing is a part of DNA structure & maintains a symmetrical double helix

Experiment: Determination that DNA contains equal amounts of guanine and cytosine and of adenine and thymine

DNA replication is semiconservative, not conservative or dispersive

Experiment: Density shift experiments

DNA is the hereditary material

Experiment: Discovery that bacteria can transfer a "factor" that transforms a harmless strain into a lethal one.

DNA, not protein, is the hereditary material

Experiment: Blender experiments that showed that the part of a virus that infects bacteria contains phosphorus, but not sulfur

ribose

which chemical is not a part of DNA: nitrogen, ribose, cytosine, phosphate

DNA

Okazaki fragments are small pieces of what?

all of these

Structure of DNA - 1 turns to form a helix 2 is symmetrical 3 is antiparallel, 4 pairs purines with pyramidines 5 all of these

Watson and Crick

who used models to deduce the double helical shape of DNA?

Meselson and Stahl

Who performed experiments to show that DNA replication is semi-conservative?