Chapter 18

mitochondria

this is where oxidative phosphorylation occurs in eukaryotes

respiration

an atp generating process in which an inorganic substance such as oxygen serves as the ultimate electron acceptor

porins

the permeability of the outer mitochondrial membrane is primarily due to the presence of these substances

coenzyme Q

these enzymes play a key role in apoptosis

this enzyme catalyzes the reduction of O2

cytochrome c oxidase

iron sulfur clusters

this prosthetic group is present in complex I, II, and III of electron transport

succinate dehydrogenase

this citric acid cycle enzyme is also part of an electron transport complex

caspase

this is the name given to the hypothesis proposed by peter mitchell to explain how ATP synthesis is coupled to electron transport

ATP-ADP translocase

atractyloside inhibits this mitochondrial protein

Malate- aspartate shuttle

this is a process by which cytoplasmic NADH can be re-oxidized by O2 using the electron transport system

proton motive force

the unequal distribution of H across the inner mitochondrial membrane creates a _____

FMN

in the initial step of complex I, two high potential electrons are transferred from NADS to the _____ prosthetic group of this complex

C

Cytochrome ____ is the only water soluble cyctochrom of the electron transport chain

Cytochrome C

carries electrons from complex III to IV

superoxide

the transfer of a single elctron to O2 forms the reactive ____ ion

ATP synthase

a molecular assembly in the inner mitochondrial membrane that carries out the synthesis of ATP

dihydroxyacetone phosphate

in the glycerol phosphate shuttle, cytoplasmic glycerol phosphate dehydrogenase uses cytoplasmic NADH to reduce _______ to glycerol 3 phosphate

ADP

acceptor control of oxidative phophorylation means that the rate of respiration depends upon the level of _____

carbon monoxide

a poison becuase it blocks the flow of elctrons from cytochrome c to oxygen

what type of gradient is critical to ATP formation by oxidative phophorylation?

pH and proton

When glucose it totally oxidized to CO2 and H2O, how many ATP molecules are made by oxidative phophorylation relative to the maximum yield?

26 out of 30

What is the chemical effect of oligomycin on aerobic metabolism

oligomycin blocks the proton transfer through F of ATP synthase and therefore blocks the phosphorylation of ADP to for ATP

which of the following does not participate in, nor is a component of, the electron transport chain?

lipoic acid

in prokaryotes the site of ATP synthesizing machinery is

the cytoplasmic membrane

Electron flow down the elctron transport chain leads to____

transport of protons across the inner mitochondrial membrane from inside the matrix to the intermembrane space

which electron carrier is a derivative of quione and has an isporenoid tail

coenzyme Q

which of the following does not pump protons

complex II

The energy for ATP synthesis is generated by th emovement of protons from the _____ side of the inner mitochondrial membrane establishing a gradient

matrix; pH

what is a cytochrome

a protein that transfers electrons, and that also contains a heme prosthetic group

in the Rieske center, the iron sulfur center is coordinated to the amino acid

His

what is the net ATP obtained from one cytoplasmic NADH when it is reoxidized by the electron transport chain using the glycerol 3 phosphate shuttle?

1.5

in the malate aspartate shuttle, electrons from NADH are transferred to ____, forming malate

oxaloacetate