Chemotaxis
Movement of inflammatory cells on the site of injury
Monocytes
In blood
Macrophage
In tissue
PLA2
Phospholipids > Arachidonic acid
PLC
Phosphatidylinositol > Arachidonic acid
COX
Arachidonic acid > Prostanoids
LOX
Arachidonic acid > Leukotrienes
LTB4
Chemotactic factor= chemotaxis (inflammation)
LTC4 and LTD4
Slow reacting subs of anaphylaxis (SRSAs)
TXA2, PGF
Vasoconstriction
PGI2, PGE Series
Vasodilator
LTC4 and LTD4
Bronchoconstriction
PGI2, PGE Series
Bronchodilation
PGE Series
Cytoprotection
PGE Series, PGF
Contraction of uterus, dysmenorrhea
TXA2
Platelet aggregation (clot)
PGI2, PGE1
Inh. Platelet aggregation (bleed)
PGF alpha
Decrease IOP
Misoprostol (Cytotec)
PGE1 analog; Cytoprotection
Misoprostol
Tx of NSAID induced ulcer; abortifacient
Epoprostol
PGI2 analog; vasodilation (Mgt of primary pulmonary HTN)
Dinoprostone
PGE2 analog; cervical ripening; abortifacient
Alprostadil
PGE1 analog, vasodilation; mgt of erectile dysfunction
Latanoprost
PGF2 alpha analog; Mgt of glaucoma