aminosalicylates
dec GI inflammation thru direct contact w bowel mucosa
systemic
sulfasalzine, mesalamine, olsalazine, balsalazide and topical: 5- ASA enema, mesalamine suppositories
antimicrobials
to prevent or treat secondary infections
metronidazole, ciprofloxacin, clarithromycin
corticosteroids
dec inflammation
prednisone, budesonide, hydrocortisone, methylprednisolone (IV for severe IBD), topical- hydrocortisone suppositories, foam, or enema
immunosuppressants
azathioprine, methotrexate, anti- TNF Infliximab, adalimumab
IV Corticosteroids
- preserved for most severe cases
- give the shortest period of time
- taper doses slowly and taper to lowest possible levels when surgery is planned to prevent post- op complications
- Do NOT take with immunosuppressants- they can cause bone marrow suppr
biologic and targeted therapy
inhibit TNF, prevent leukocytes from getting to inflamed tissue
anti- TNF angents
infliximab, adalimumab, certolizumab pegol, and golimumab
natalizamab
inhibits leukocyte adhesion
antidiarrheals
dec GI motility
hematinic and vitamins
correct iron deficiency, promote healing
hematinic
is a nutrient required for the formation of blood cells in the process of hematopoiesis. the main hematinics are iron, B12, and folate. deficiency in hematinics can lead to anemia