Chapter 1 Microbiology - Then and Now

Microorganisms

microscopic living organisms

Microbes

Any microscopic organism. Mainly bacteria, protists, some fungi, and even some tiny multi-cellular organisms.

Disease

Caused by a pathogen

Pathogen

An organism that causes disease

Bacteriology

Study of bacteria

Virology

The study of viruses

Protozoology

Study of protozoa

Phycology

Study of algae

Immunology

The study of immunity

Parasitology

Study of parasites

Epidemiology

A branch of medical science that deals with the incidence, distribution, and control of disease in a population

Mycology

Study of fungi

Microbiota

the term for the microbes that are normally present in and on the human body; usually beneficial

Pathogens

Microbes that cause disease

Convex

curved outward

Robert Hooke

The English scientist who first identified cells in living matter (cork) was

Anton Von Leeuwenhoek

developed the earliest form of the microscope and made it popular due to his drawings of "animalcules

Animalcules

Leeuwenhoek called the unicellular microorganisms that he observed

Spontaneous Generation

Hypothesis stating that life could arise from nonliving matter.

Francesco Reddi

Tried to disprove the theory of spontaneous generation. The independent variable in his experiment was types of jar coverings and Dependent variable was the number of flies on the meat.

Lazzaro Spallanzani

1765 boiled in flasks vital force needed for spontaneous generation destroyed by heat

John Needham

claimed that spontaneous generations occurs under the right conditions

Miasma

Bad air

Louis Pasteur

Used his swan necked flasks, finally laid to rest the idea of spontaneous generation (abiogenesis).

Ignaz Semmelweis

demonstrated that washing hands between patients in a maternity ward could reduce the spread of "child-bed fever

Variolation

early chinese approach to introducing immunity to non-exposed individuals

Edward Jenner

British physician who introduced a vaccine to prevent smallpox that involved inoculation using cowpox germs

IRB

Institutional Review Board

John Snow

Epidemiologist (Medical Geography) - control of epidemics link between water supply and cholera - mapped cholera deaths and location of water wells/pumps.

Vaccination

injection of a weakened or mild form of a pathogen to produce immunity

Bacteria

single-celled or noncellular spherical or spiral or rod-shaped organisms lacking chlorophyll that reproduce by fission

Jacob Henle

thought that living organisms could cause disease

Fermentation

A splitting of sugar molecules into simpler products. Alcohol, acid, and gas (CO2)

Pasteurization

A process of heating food to a temperature that is high enough to kill most harmful bacteria without changing the taste of the food.

Germs

Pathogens

Germ Theory

the theory that infectious diseases are caused by certain microbes

Joseph Lister

English surgeon who was the first to use antiseptics

Antisepsis

Removing pathogens from living tissue

Robert Koch

The founder of modern bacteriology, he is known for his role in identifying the specific causative agents of tuberculosis, cholera, and anthrax and for giving experimental support for the concept of infectious disease

Bacilli

Rod shaped bacteria

Koch's Postulates

Experimental steps to prove a specific microbe causes a specific disease

Colonies

Collections of autonomously replicating cells.

Agar

a gel-like polysaccharide compound used for culturing microbes; extracted from certain red algae

Broth

A liquid tube containing nutrients to enhance growth

Pure Culture

contains only one species or strain

Fanny Hesse

Who developed the use of agar as a solidifying agent for microbiological media

Julius Petri

invented the double sided Petri dish in 1887 for the culture of microbes

Dimitri Ivanowski

Discovered tobacco mosaic virus in plant extracts. The extracts would cause disease after bacteria were removed

Nitrogen Fixation

Process of converting nitrogen gas into ammonia

Cyanobacteria

Bacteria that can carry out photosynthesis

Decomposers

Organisms that break down the dead remains of other organisms

Archaea

Domain of unicellular prokaryotes that have cell walls lacking peptidoglycan. Like eukaryotes, DNA contains histone proteins.

Viruses

Pieces of genetic material surrounded by a protein coat

Fungi

A kingdom made up of nongreen, eukaryotic organisms that have no means of movement, reproduce by using spores, and get food by breaking down substances in their surroundings and absorbing the nutrients

Protista

Kingdom composed of eukaryotes that are not classified as plants, animals, or fungi

Prokaryotic

An organism whose cells do not have an enclosed nucleus, such as bacteria.

Eukaryotic

A cell characterized by the presence of a nucleus and other membrane-bound organelles. Eukaryotes can be unicellular (protists) or multicellular (fungi, plants and animals).

Paul Ehrlich

Discovered that certain dyes stained microorganisms but not animal cells, suggesting that the dyes or other chemicals might selectively kill microbial cells. This gave him the idea of a "magic bullet," a chemical that would destroy specific bacteria witho

Chemotherapy

The use of drugs to treat diseases such as cancer

Antibiotic

A chemical secreted by a living organism that kills or reduces the reproduction rate of other organisms

Alexander Flemming

Discovered penicillin

Biotechnology

A form of technology that uses living organisms, usually genes, to modify products, to make or modify plants and animals, or to develop other microorganisms for specific purposes.

Classical Golden Age

1854-1914 - Many branches of microbiology are established.

Second Golden Age

1943-1970 -WWI slowed down discovery because there was no more sharing and countries kept to themselves

Third Golden Age

NOW! Fighting antimicrobial resistance, emerging and re-emerging infectious diseases, bioterrorism, but discovered biofilms, bioremediation, genomics and bioinformatics

Polymicrobial Diseases

diseases caused by two or more microbes acting together in succession

Emerging Infectious Diseases

infectious disease that has newly appeared in the population or that has been known but is rapidly increasing in incidence or geographic range

Reemerging Infectious Diseases

diseases that once were major health problems globally or in a particular country, and then declined dramatically, but are again becoming health problems for a significant proportion of the population (malaria and tuberculosis are examples).

Bioterrorism

the use of biological and chemical weapons in terrorist attacks

Antibiotic Resistance

Resistance evolving rapidly in many species of prokaryotes due to overuse of antibiotics, especially in agriculture.

Bioremediation

The use of living organisms to detoxify and restore polluted and degraded ecosystems