TRUE FALSE 1. DiGeorge syndrome is an example of a humoral immunodeficiency syndrome.
FALSE; cell-mediated
TRUE FALSE 2. Type I hypersensitivities are mediated by IgA and the phagocytic response.
FALSE; IgE and the histamine/inflammatory response
TRUE FALSE 3. SCID is self-limiting and kids usually outgrow it.
FALSE; usually die young without bone marrow transplant or ADA replacement
TRUE FALSE 4. There is no treatment for Selective IgA Deficiency (SIGAD).
TRUE
TRUE FALSE 5. Vaccinations with live attenuated organisms can be given to children with primary immunodeficiency disorders.
FALSE; SHOULD NOT, it could kill them
TRUE FALSE 6. Chediak-Higashi syndrome can present as a bleeding disorder.
TRUE
TRUE FALSE 7. IgM is the type of antibody that you would find in a mother's breast milk.
FALSE; IgA
TRUE FALSE 8. IgG is the type of antibody that can cross the placenta.
TRUE
9. ______________________________is the term for a dz where the body's immune cells mount an attack against self tissues.
Autoimmune disease
10. ____________________________ is the term for lab tests that check for a certain antibody in a patient's plasma.
Serology
11. _____________________________is the name of the skin test that checks for tuberculosis.
Mantoux skin test
12. A patient with a selective IgA deficiency is to receive a transfusion of packed red blood cells. The nurse should double-check to make the RBCs have been _____________________ prior to transfusion.
Washed
13. Why do kids with DiGeorge syndrome have hypocalcemia? What are the signs and symptoms of hypocalcemia?
-Congenital abnormality of the thymus, which develops at same time as parathyroid gland
-PTH deficient due to parathyroid disfunction
-Without PTH --> develop hypocalcemia
S & S:
-exaggerated reflexes
-muscle spasms and tetany
-carpopedal spasm
-laryngosp
14. Tell me 6 ways that anaphylaxis may be treated:
-AVOID contact with allergen
-Adrenergic agonists (Epinephrine via Epipen)
-Antihistamines
-Corticosteroids
-Anticholinergics
-Anti-Immunoglobin E Rx
-Oxygen therapy
15. What are 2 ways to treat graft vs. host disease?
-Remove or destroy T cells in transplanted tissue
-Immunosuppressive drugs given to the recipient
16. What are the important warning signs that a child may have a primary immunodeficiency disorder?
-FTT
-Multiple ear, sinus, lung infections
-Deep skin or organ abscesses
-Need for IV antibiotics to clear infection
-Family hx of immunodeficiency
17. The T lymphocytes in a transplanted liver begin a cell-mediated reaction to the tissues in the transplant recipient. This describes:
a) transplant rejection
b) graft vs host disease
B; Graft vs. Host disease
_________ CD8+ cells recognize altered MHC I of infected cells and destroy them
Type IV Cell-mediated Hypersensitivity
_________ antigen binds to IgE on mast cells and basophils, resulting in the release of histamine
Type I Immediate Hypersensitivity
_________ antigen/antibody complexes lodge in tissues and cause inflammation and activation of phagocytes
Type III Immune-Complex mediated Hypersensitivity
_________ Antibodies bind antigens on cells, resulting in change in or destruction of those cells
Type II Antibody-mediated Hypersensitivity
_________ CD4+ cells secret cytokines that result in chemotaxis and inflammation
Type IV Cell-mediated Hypersensitivity
__________ SLE (systemic lupus erythematosus) and RA (rheumatoid arthritis)
Type III Immune-Complex mediated Hypersensitivity
__________ contact dermatitis from poison ivy
Type IV Cell-mediated Hypersensitivity
__________ Anaphylaxis from eating peanuts when you have a peanut allergy
Type I Immediate Hypersensitivity
__________ Grave's dz and Myasthenia Gravis
Type II Antibody-mediated Hypersensitivity
__________ transplant rejection
Type IV Cell-mediated Hypersensitivity