Pathology II - Chapter 9

4.5 to 6 million

Normal blood cell count - RBC

14g in women and 15g in men per deciliter

Normal blood cell count - Hemoglobin

5,000 to 10,000/mm3

Normal blood cell count - WBC

55-75% of WBC

Normal blood cell count - Neutrophils

1-4% of WBC

Normal blood cell count - Eosinophils

0-1% of WBC

Normal blood cell count - Basophils

25-40% of WBC

Normal blood cell count - Lymphocytes

2-8% of WBC

Normal blood cell count - Monocytes

150,000 to 400,000mm/3

Normal blood cell count - Platelets

Eosinophils

Red-staining cells whose number greatly increases in allergic and parasitic conditions

Neutrophils

Polymorphonuclear leukocytes which make up 55-75% WBC, defend the body against bacteria by ingesting these foreign organisms and destroying them (phagocytosis), the number increases enormously in acute infections because the bone marrow rapidly releases i

Leukocytes

WBC, produced in both red marrow and lymphoid tissue; normally number from 5000 to 10,000/mm3 of blood; several types of WBC: Neutrophils, Eosinophils, Basophils, Lymphocytes, Monocytes

Hemoglobin

Iron-based protein that carries oxygen from the respiratory tract to the body's tissues; erythrocytes contain these; 14g in women and 15g in men per deciliter

Erythrocytes

RBC, Biconcave disks without a nucleus that contain hemoglobin; 4.5 to 6 million RBC in each cubic millimeter of blood

Thrombocytes

Platelets, smallest blood cells essential for blood clotting; 150,000 to 400,000 in every cubic millimeter of blood

Lymphoma

Radiographic appearance:
Chest image - Mediastinal lymph node enlargement seen on initial chest radiographs of about half the patients with Hodgkin's disease and about one third of those with non-Hodgkin's lymphoma; usually bilateral but asymmetric;
GI se

Thalassemia

Radiographic appearance:
Generalized osteoporosis with pronounced widening of the medullary spaces and thinning of the cortices in long and tubular bones; as the fine secondary trabeculae are resorbed, new bone is laid down on the surviving trabeculae, th

Leukemia

Neoplastic proliferation of WBC, may be chronic or acute; diffuse infiltration of WBC into the spleen and liver may cause massive enlargement of these organs (hepatosplenomegalyl); two major types are named for site of malignancy: Myelocytic and Lymphatic

Myelocytic leukemia

A cancer of the bone marrow, a huge increase in the number of circulating granulocytes occurs, and the production of red blood cells and platelets is decreased

Lymphatic leukemia

Malignancy of the lymph nodes, the only WBC that dramatically increase are lymphocytes

Hemophilia

An inherited (by sex-linked recessive gene) anomaly of blood coagulation that appears clinically only in males; decrease serum concentration or absence of antihemophilic globulin (factor VII) and suffer a lifelong tendency to spontaneous hemorrhage or sev

Anemia

Refers to a decrease in the amount of oxygen-carrying hemoglobin in the peripheral blood which can be attributable to improper formation of new RBC, an increased rate of RBC destruction, or a loss of RBC as a result of prolonged bleeding; hemoglobin defic

Hodgkin's disease

One of two major types of lymphoma; 99% of cases of this disease originate in the lymph nodes; 10% are of extranodal origin

Primary polycythemia

Polycythemia vera, hematologic disorder characterized by hyperplasia of the bone marrow (neoplastic) that results in increased production of erythrocytes, granulocytes, and platelets; slowly progressive and produces symptoms associated with increased bloo

Infectious mononucleosis

Self-limited viral disease of the lymphoreticular system characterized by vague symptoms of mild fever, sore throat, and swollen lymph nodes caused by an intense increase of lymphoid cells; Epstein-Barr virus may cause this disease process; primarily infe

Purpura (thrombocytopenia)

Refers to a deficiency in the number of platelets and it results in spontaneous hemorrhages in the skin, mucous membranes of the mouth, and internal organs; results from decreased production, increased destruction, or splenic sequestration of platelets; i

Iron deficiency anemia

The most common cause of anemia; results from chronic blood loss, as from an ulcer, a malignant tumor, or excessive bleeding during menstruation (menorrhagia); other causes are inadequate dietary intake of iron and increased iron loss caused by intestinal

Hemolytic anemia

Underlying abnormality in this is a shortened life span of the RBC with resulting hemolysis and the release of hemoglobin into the plasma; caused by hereditary defect that may produce abnormal RBC or abnormal hemoglobin; less commonly acquired and related

Thalassemia anemia

Occurs predominantly in persons living near the Mediterranean Sea, especially those of Italian, Greek, or Sicilian descent; a defect in hemoglobin formation can also be responsible for this

Sickle cell anemia

Anemia characterized by crescentic RBC that contain abnormal hemoglobin molecules and are susceptible to rupture; generally confined to African Americans

Aplastic anemia

A generalized failure of the bone marrow to function results in decreased levels of erythrocytes, leukocytes, and platelets; pt cannot fight infection (a white blood cell function) and has a bleeding tendency (platelet depletion); causes include exposure