Pathophysiology CH2

Glycolipids

carbohydrate bound to lipid, help make up lipid bilayer in plasma membrane

Transmembrane proteins

proteins that pass through the membrane

Integral proteins

specific type of transmembrane protein that becomes part of the membrane

Channel proteins

allow for the transport of ions across the plasma membrane

Cytoskeleton

Composed of tubule and filament structures that contribute to cell shape, movement, and intracellular transport

Membrane potential

charge inside a cell membrane in relation the surrounding extracellular fluid

Primary active transport

requires the direct use of energy in the form of ATP

Secondary active transport

depends on energy derived from the active transport of the primary substance

Cotransport

transported in the same direction

Endocytosis

used to transport large substances into cells

Pinocytosis

the ATP-requiring process of ingesting small vesicles

Phagocytosis

the process of ingesting large particles

Cellular respiration

a series of metabolic processes that transforms fuel molecules into energy and waste products

Glycolysis

process of breaking down glucose in the cytosol of the cell

Feedback mechanisms

regulate gene activation to tightly control the production of proteins and to prevent cell damage caused by overproduction or underproduction

Ligand

signaling molecules

Signal transduction pathway

when a ligand binds to a receptor, the target cell begins the process of communication

Paracrine signaling

ligand-receptor binding that results in signal transduction with a local effect

Proliferation

increase in cell number

Differentiation

changes in physical and functional properties of cells, directs the cell to develop into specific cell types

Endoplasmic Reticulum

produces proteins and fats

Endoplasmic Reticulum

regulates ions within the cell

Rough Endoplasmic Reticulum

synthesizes proteins

Rough Endoplasmic Reticulum

produces lysosomal enzymes

Smooth Endoplasmic Reticulum

synthesizes lipids, lipoproteins, and steroid hormones

Smooth Endoplasmic Reticulum

regulates intracellular calcium

Golgi Apparatus

prepares substances produced by the endoplasmic reticulum for secretion out of the cell

Lysosome

digests cellular debris with hydrolytic enzymes

Peroxisomes

contains oxidase that neutralizes oxygen free radicals

Oxygen free radicals

atoms carrying an unpaired electron and no charge

Peroxisomes

neutralize harmful substances

Proteosomes

recognize abnormally folded or formed proteins

Proteolysis

breakdown of proteins used by proteosomes

Mitochondria

contain cytochrome enzymes

Mitochondria

contain enzymes needed for the citric acid cycle, fatty acid oxidation, and oxidative phosphorylation