Pharmaceutics: Sessions 7-10 Exam

What is the therapy or technology based on a complementary nucleotide blocking the synthesis of a disease-causing protein?

Nucleotide blockage/antisense technology

What is the therapy or technology where DNA is inserted into patient's cells replacing missing or defective ones?

Gene therapy

What is the smallest antibody fragment?


What kind of mAb is Trastuzumab (Herceptin)?


Based on the suffix mAb, which of these would be LEAST immunogenic? Detumomab, Ofatumab, or Rituximab?


Which of these is a cell-therapy product? Nivolumab, Nursinesen, Talmogene laherparepvec, or Tisagenlecleucel


Which protein structure consists ONLY of covalent bonding between amino acids?


The following are non-ionic surfactants used to prevent shear-induced aggregation in protein products except? Polysorbate-80, Polysorbate-20, Sodium-lauryl sulfate

Sodium lauryl sulfate

The following are non-reducing sugars used to stabilize protein conformation except? Glucose, Mannitol, Sucrose, or Trehalose


What is the function of citric acid and sodium citrate in the Epogen formulation?

Buffering agent

What is the function of benzyl alcohol in the Epogen formulation?


Which of the deamidation products of asparagine is more likely to impact protein conformation?

Iso-Aspartic Acid

Which of these would most likely produce the highest incidence of "human anti-mouse antibody" response (highest human immune response against mouse antibodies)?

Murine antibody