What is the therapy or technology based on a complementary nucleotide blocking the synthesis of a disease-causing protein?
Nucleotide blockage/antisense technology
What is the therapy or technology where DNA is inserted into patient's cells replacing missing or defective ones?
Gene therapy
What is the smallest antibody fragment?
sFv
What kind of mAb is Trastuzumab (Herceptin)?
Humanized
Based on the suffix mAb, which of these would be LEAST immunogenic? Detumomab, Ofatumab, or Rituximab?
Ofatumab
Which of these is a cell-therapy product? Nivolumab, Nursinesen, Talmogene laherparepvec, or Tisagenlecleucel
Tisagenlecleucel
Which protein structure consists ONLY of covalent bonding between amino acids?
Primary
The following are non-ionic surfactants used to prevent shear-induced aggregation in protein products except? Polysorbate-80, Polysorbate-20, Sodium-lauryl sulfate
Sodium lauryl sulfate
The following are non-reducing sugars used to stabilize protein conformation except? Glucose, Mannitol, Sucrose, or Trehalose
Glucose
What is the function of citric acid and sodium citrate in the Epogen formulation?
Buffering agent
What is the function of benzyl alcohol in the Epogen formulation?
Preservative
Which of the deamidation products of asparagine is more likely to impact protein conformation?
Iso-Aspartic Acid
Which of these would most likely produce the highest incidence of "human anti-mouse antibody" response (highest human immune response against mouse antibodies)?
Murine antibody