Top 76-150: BPH and Bladder Drugs: M

Proscar

finasteride

tablets: 5mg

finasteride

BPH

finasteride

competitively inhibits 5-alpha-reductase, which metabolizes testosterone to DHT (prostate growth)

finasteride

contraindicated in women and children
women who are pregnant or plan to become pregnant should not handle or be exposed to semen from a pt taking finasteride

finasteride

depression
erectile dysfunction
decreased libido
male infertility

finasteride

monitor: PSA

finasteride

Bentyl

dicyclomine HCl

anticholinergic

dicyclomine HCl

capsules: 10mg
tablets: 20mg
syrup: 10mg/5mL
injection: 10mg/mL

dicyclomine HCl

functional/irritable bowel syndrome

dicyclomine HCl

inhibits ACh at postganglionic parasympathetic receptor sites in smooth muscle, secretory gland tissue, and CNS

dicyclomine HCl

contraindicated in urinary tract or intestinal obstruction, intestinal atony, unstable cardiovascular status in acute hemorrhage, myasthenia gravis, severe ulcerative colitis, paralytic ileus, glaucoma, less than 6mo
caution in prostatic hypertrophy, auto

dicyclomine HCl

dizziness
headache
nausea
vomiting
dry mouth
drowsiness
constipation
difficulty in urination

dicyclomine HCl

avoid alcohol

dicyclomine HCl
tolterodine tartrate

Detrol (LA)

tolterodine tartrate

muscarinic antagonist

tolterodine tartrate

tablets: 1mg, 2mg
capsules, ER: 2mg, 4mg

tolterodine tartrate

overactive bladder with symptoms of urinary frequency, urgency, or urge incontinence

tolterodine tartrate

competitive muscarinic receptor antagonist
increase residual urine due to incomplete emptying of bladder
decrease in detrusor pressure

tolterodine tartrate

contraindicated in urinary retention, gastric retention, uncontrolled narrow-angle glaucoma
caution in impaired hepatic or renal function, bladder outflow obstruction, pyloric stenosis
discontinue during nursing

tolterodine tartrate

dry mouth
headache
dizziness
constipation
dyspepsia
somnolence
blurred vision

tolterodine tartrate

myrbetriq

mirabegron

beta-3 adrenergic agonist

mirabegron

tablets, ER: 25mg, 50mg

mirabegron

overactive bladder with symptoms of urge urinary incontinence, urgency, urinary frequency

mirabegron

beta-3 adrenergic agonist
relaxes smooth detrusor muscle during storage or urine
greater bladder capacity

mirabegron

not recommended in severe, uncontrolled HTN, end stage renal disease, or severe hepatic impairment
caution in bladder outlet obstruction, severe renal or moderate hepatic impairment, and nursing

mirabegron

HTN
UTI
urinary retention
headache
nasopharyngitis
afib
angioedema
prostate cancer

mirabegron

take with or without food
swallow tablets whole

mirabegron