bone marrow suppression
Name the primary toxicity associated with bolus 5-FU
mucositis or diarrhea
Name two side effects of continuous infusion 5-FU
pulmonary fibrosis
What toxicity is ass'd w/ busulfan?
diarrhea
What is the dose limiting tox of irinotecan
pulmonary fibrosis and hyperpigmentation
Name two toxicities ass'd w/ bleomycin
Kidney function (CrCL, BUN, lytes)
This organ function should be monitored in pts on cisplatin
acrolein
Name the toxic metabolite of cyclophosphamide/ifosfamide
hemorrhagic cystitis
What tox is ass'd w/ cyclophosphamide and ifosphamide?
leuprolide
This medication sold under the brand names Eligard and Lupron is a LHRH analog that works by a negative feedback mech to halt testosterone production
cold temps
Oxaliplatin induced peripheral neuropathy can be triggered with what type of stimulus?
cytarabine
Cerebellar (CNS) tox is a dose limiting side effect of what medication?
cardiotoxicity
What is the cumulative toxicity that is seen with anthracyclines?
N/V
Name the toxicity of cisplatin that requires pre-medication with a three drug combination regimen prior to every infusion
Highly emetogenic
How would cisplatin be classified based upon its emetogenicity per NCCN GL?
CYP2D6
The drug interaction between tamoxifen and paroxetine is mediated by what cytochrome P450 enzyme?
doxorubicin
Name the chemotx agent for which we should counsel patients regarding red colored urine and other bodily fluids
Vesicants
Anthracyclines are classified as ___ because if they extravasate they can cause blistering and other tissue injury that may be severe and can lead to tissue necrosis.
endometiral
Tamoxifen carries a BBW for incr risk of secondary malignancy because tamoxifen is an antagonist in breast tissue but is an agonist in ___ tissue.
acneiform rash
What is the most common SE seen with EGFT inhibs?
hypersensitivity (infusion reactions)
We pre-medicate pts rec'ing MABs to prevent what type of reaction?
vinca alkaloids
Which class of meds inhibs mitotic spindle formation by binding to tubulin
taxanes
Which class of meds promotes microtubule formation and retards disassembly resulting in mitotic arrest?
M phase
In which phase of the cell cycle do microtubule inhibitors work?
Vinca alkaloids: vincristine, vinblastine
Which anti-mitotic spindle agents have labeling that includes:
"Fatal if given intrathecally
Cremophor
Name the solubilixing agent use in the formulation of paclitaxel that may cause hypersensitivity rxs
Mesna
What antidote is given with ifosphamide or cyclcphosphamide
Ice chips
What can pts chew to prevent mouth sores (mucosistis) from MTX
amifostine
What agent can be used to minimize the nephrotoxicity of cisplatin?
dexrazoxane
What antidote is used for the tx of doxorubucin cartiotoxicity?
Leucovorin (folinic acid)
______ rescue is used to minimize MTX tox