Chemoman

bone marrow suppression

Name the primary toxicity associated with bolus 5-FU

mucositis or diarrhea

Name two side effects of continuous infusion 5-FU

pulmonary fibrosis

What toxicity is ass'd w/ busulfan?

diarrhea

What is the dose limiting tox of irinotecan

pulmonary fibrosis and hyperpigmentation

Name two toxicities ass'd w/ bleomycin

Kidney function (CrCL, BUN, lytes)

This organ function should be monitored in pts on cisplatin

acrolein

Name the toxic metabolite of cyclophosphamide/ifosfamide

hemorrhagic cystitis

What tox is ass'd w/ cyclophosphamide and ifosphamide?

leuprolide

This medication sold under the brand names Eligard and Lupron is a LHRH analog that works by a negative feedback mech to halt testosterone production

cold temps

Oxaliplatin induced peripheral neuropathy can be triggered with what type of stimulus?

cytarabine

Cerebellar (CNS) tox is a dose limiting side effect of what medication?

cardiotoxicity

What is the cumulative toxicity that is seen with anthracyclines?

N/V

Name the toxicity of cisplatin that requires pre-medication with a three drug combination regimen prior to every infusion

Highly emetogenic

How would cisplatin be classified based upon its emetogenicity per NCCN GL?

CYP2D6

The drug interaction between tamoxifen and paroxetine is mediated by what cytochrome P450 enzyme?

doxorubicin

Name the chemotx agent for which we should counsel patients regarding red colored urine and other bodily fluids

Vesicants

Anthracyclines are classified as ___ because if they extravasate they can cause blistering and other tissue injury that may be severe and can lead to tissue necrosis.

endometiral

Tamoxifen carries a BBW for incr risk of secondary malignancy because tamoxifen is an antagonist in breast tissue but is an agonist in ___ tissue.

acneiform rash

What is the most common SE seen with EGFT inhibs?

hypersensitivity (infusion reactions)

We pre-medicate pts rec'ing MABs to prevent what type of reaction?

vinca alkaloids

Which class of meds inhibs mitotic spindle formation by binding to tubulin

taxanes

Which class of meds promotes microtubule formation and retards disassembly resulting in mitotic arrest?

M phase

In which phase of the cell cycle do microtubule inhibitors work?

Vinca alkaloids: vincristine, vinblastine

Which anti-mitotic spindle agents have labeling that includes:
"Fatal if given intrathecally

Cremophor

Name the solubilixing agent use in the formulation of paclitaxel that may cause hypersensitivity rxs

Mesna

What antidote is given with ifosphamide or cyclcphosphamide

Ice chips

What can pts chew to prevent mouth sores (mucosistis) from MTX

amifostine

What agent can be used to minimize the nephrotoxicity of cisplatin?

dexrazoxane

What antidote is used for the tx of doxorubucin cartiotoxicity?

Leucovorin (folinic acid)

______ rescue is used to minimize MTX tox