Alkylating Agents MOA
Alkylation of DNA at N-7 guanine and form cross-links
Alkylating SE
Myelosuppression
Mucocistis
Aleopecia
N/V
Alkylating Agents are
Non-specfic
Antimetabolites MOA
False agents
Antimetabolites SE
Myelosuppression
Mucositis
N/V
Antimetabolites Cell Cycle
Specific S phase
Anti-microtubule Agents Cell cycle
Specific M Phase
Anti-microtubule Agent MOA
interferes w/ spindle formation
stabilize microtubule
prevent cell division
Anti-microtubule Agents include MVET
Miscellaneous
Vinca Alkalods
Epothilones
Taxanes
Epigenetic Modifying Agents MOA
Inhibit histone deacetylase (HDAC)
Epigenetic Modifying Agents MOA
Myelosuppression
Cardiac
Epigenetic Modifying Agents
Belinostat
Romidepsin
Panobinostat
Vorinostat
Topoisomerase I Inhibitors Cell Cycle
Specific
Topoisomerase II Inhibitors Cell Cycle
Non-specific
Topoisomerase Inhibitors MOA
Bind to Top-DNA complex
Prevent relegation of cleaved DNA
Some have many MOA
Topoisomerase Inhibition SE
Myelosuppression
Nausea
Vesicant | extravasation (except liposomal products)
Topoisomerase I inhibitors
Irinoteacan
Irinotecan Liposomal
Topotecan
Topoisomerase II Inhibitors
Anthracyclines
Anthracenedione
Epipodophyllotoxins
Anthracyclines
Daunorubicin
Daunorubicin, liposomal
Doxorubicin
Doxorubicin, liposomal
Epirubicin
Idarubicin
Valrubicin
Anthracenedione
Mitoxantrone
Epipodophyllotoxins
Etoposide
Etoposide Phosphate
Teniposide
Color
Doxorubicin - Red
Idarubicin - Orange
Mitoxantrone - Blue Urine Green
Drug Resistance
Inherited | Acquired
? Activation Prodrug
? Drug uptake
? in targent enzymes
Alt. of abbility to repair drug-induced damage
?drug inactivation
What are the Resistance Efflux pumps
P-g
Multidrug resistance associated protein (MRP)