Chapter 24 - Bioeffects

What is a microprobe?

small transducer that measures the characteristics of a sound beam

What is another name for a microprobe?

hydrophone

How is a hydrophone used?

it is placed in the sound beam and a voltage from the hydrophone relates to the sound beams pressure and is displayed on the oscilloscope

Does a hydrophone measure at specific locations?

yes

What is the benefit of using a hydrophone?

determines sound beams shape
can measure intensity and output from signal

What can a hydrophone measure?

period, PRP, PRF and pulse durationintensity

What can be measured with a calibrated hydrophone?

intensity

What is typically lowest when performing gray scale imaging?

transducer output

What is typically higher with pulsed doppler?

transducer outputt

What is radiation force?

a force created by the transducers sound beam

What is a feedback microbalance?

measured force of the beam relates to the power in the beam

What is a Schlieren?

a shadowing system that allows you to view the shape of a sound beam in a medium

What is acousto-optics?

interaction of sound and light that allows us to view the sound beam in the medium

What are three devices that measure absorption?

calorimeter
thermocouple
liquid crystal

What is absorption?

the conversion of sound energy to heat

What is a calorimeter?

measures the power of a sound beam through absorption

How does a calorimeter measure the sound beams power?

the temperature rise and time of heating

What is the difference between a thermocouple and calorimeter?

a thermocouple measures the beams power at a specific location, whereas the calorimeter measures the power of the entire beam

How do liquid crystals show beams power?

color change

What must be true about the risk of ultrasound?

that the benefit outweigh the risks

What is dosimetry?

the science of identifying and measuring the characteristics of an ultrasound beam that are relevant to its potential for producing biological effects

What is in vivo?

research performed within a living body

What is research performed within a living body?

in vivo

What is in vitro?

research performed outside a living body

What is research performed outside a living body?

in vitro

What can in vitro research indicate about intensities?

that the sound intensities are very high and can cause genetic damage and cell death

Is in vitro bioeffect research important?

yes

What are the two techniques used to study bioeffects?

mechanistic and empirical

What is a mechanistic approach?

searches for a relationship between cause and effect

What is an empirical approach?

searches for a relationship between exposure and response

Which approach - mechanistic or empirical is best with regard to studying bioeffects?

when they are in agreement

What are the two mechanisms of bioeffects?

thermal and cavitation

What is another term for cavitation?

nonthermal

What is the thermal mechanism of bioeffect?

proposes that bioeffects result from tissue temperature elevation

What is the thermal index?

a predictor of max temp increase under clinically relevant conditions

What are the 3 thermal indices

soft tissue index - TIS
bone thermal index - TIB
cranial bone thermal index - TIC

What type tissue elevation do thermal indices estimate?

in vivo

What is the empirical finding associated with thermal mechanism?

a combination of temperature and exposure time determine liklihood of harmful effects

What is the maximal heating combination?

SPTA

What is the nonthermal mechanism?

consist of cavitation and radiation force

What is cavitation?

interaction of sound waves with microscopic, stabilized gas bubbles in the tissues

What are the gas bubbles known as in cavitation?

gaseous nuclei

What is radiation force?

sheer stresses and streaming of fluids can distort biologic structures

What are the two forms of cavitation?

stable and transient

What is stable cavitation?

when gaseous nuclei expand and contract, but DO NOT burst

What is transient cavitation?

when the microbubbles burst

Why are the destructive effects of transient cavitation no considered clinically important?

because they are highly localized and only affect a few cells

What is a mechanical index?

a calculated number related to the liklihood of harmful bioeffects from cavitation

What are the characteristics of a higher MI?

more cavitation
more pressure
lower frequency

What are the characteristics of a lower MI?

less cavitation
less pressure
higher frequency

What is epidemiology?

branch of medicine associated with population studies

What type of study is epidemiology?

empirical

What are the limitations of epidemiologic studies?

retrospective
ambiguous
mulitple risk factors

What makes an epidemiologic study better?

prospective and randomized

What causes the greatest risk to electrical safety with ultrasound?

electrical shock from a cracked transducer housing

What does ALARA stand for?

As Low As Reasonably Achievable

What is cavitation?

the interaction between sound waves and small gas bubbles that exist in tissues

What are additional names for normal cavitation?

inertial and transient

What two mechanisms are likely to induce bioeffects?

thermal and mechanical