What spirochete causes syphilis?
a)Borrelia
b)Treponema
c)Leptospira
b) Treponema
What spirochete causes both lyme disease and relapsing fever?
a)Borrelia
b)Treponema
c)Leptospira
a)Borrelia
What two spirochetes have a small genome size?
Borrelia and Treponema
Are chromosomes linear or circular in Borrelia?
Linear
Are plasmids in Borrelia linear or circular?
they're BOTH bissssh
How many types of circular chromosomes are there in Leptospira?
Two
What two spirochetes have high genetic variability?
Borrelia and Leptospira
Which of the three spirochetes cannot be grown in vitro?
Treponema
Which one of the three spirochetes have a high G+C ?
Treponema
Borrelia ______________ and Borrelia __________ cause relapsing fever
recurrentis
hersmii
Which relapsing fever is louse-borne?
Borrelia hermsii or Borrelia recurrentis
Borrelia recurrentis
Which relapsing fever is tick-borne?
Borrelia hermsii or Borrelia recurrentis?
Borrelia hermsii
Which relapsing fever vector has no known animal reservoir?
Louse-borne
Incubation period for relapsing fever is _____ days
7 days
What two drugs should one use to treat relapsing fever?
Penicillins
Tetracyclines
Borrelia ______ causes Lyme Disease
Borrelia burgdoferi
Lyme disease is transmitted by ______
Ixodes ticks
Pathogensesis (transmission to mammal) is fast or slow? How many hours?
SLOW -- 24 hours
ECMs are what associated with lyme disease?
Weird ass lesions that look like donuts
What drugs are used to treat lyme disease?
Penicillin, ceftriaxone, tetracyclines
Treponema pallidum causes ______
Syphillis
Why are treponemas highly dependent on host cells?
They have NO pathways for for synthesis of fatty acids, nucleotides, amino acids
No Kreb's cycle
No respiratory ETC
What is a tertiary consequence of untreated syphillis if it becomes a CNS infection?
Gumma (gross ass lesions)
What surface exposed protein accounts for persistence of syphillis infection due to antigenic variation?
TprK
In order, what drugs does one use to treat syphillis?
1) Penicillin
2)Doxycycline, tetraycycline
3) Macrolides (but has high rates of resistance)
What spirochete causes syphilis?
a)Borrelia
b)Treponema
c)Leptospira
b) Treponema
What spirochete causes both lyme disease and relapsing fever?
a)Borrelia
b)Treponema
c)Leptospira
a)Borrelia
What two spirochetes have a small genome size?
Borrelia and Treponema
Are chromosomes linear or circular in Borrelia?
Linear
Are plasmids in Borrelia linear or circular?
they're BOTH bissssh
How many types of circular chromosomes are there in Leptospira?
Two
What two spirochetes have high genetic variability?
Borrelia and Leptospira
Which of the three spirochetes cannot be grown in vitro?
Treponema
Which one of the three spirochetes have a high G+C ?
Treponema
Borrelia ______________ and Borrelia __________ cause relapsing fever
recurrentis
hersmii
Which relapsing fever is louse-borne?
Borrelia hermsii or Borrelia recurrentis
Borrelia recurrentis
Which relapsing fever is tick-borne?
Borrelia hermsii or Borrelia recurrentis?
Borrelia hermsii
Which relapsing fever vector has no known animal reservoir?
Louse-borne
Incubation period for relapsing fever is _____ days
7 days
What two drugs should one use to treat relapsing fever?
Penicillins
Tetracyclines
Borrelia ______ causes Lyme Disease
Borrelia burgdoferi
Lyme disease is transmitted by ______
Ixodes ticks
Pathogensesis (transmission to mammal) is fast or slow? How many hours?
SLOW -- 24 hours
ECMs are what associated with lyme disease?
Weird ass lesions that look like donuts
What drugs are used to treat lyme disease?
Penicillin, ceftriaxone, tetracyclines
Treponema pallidum causes ______
Syphillis
Why are treponemas highly dependent on host cells?
They have NO pathways for for synthesis of fatty acids, nucleotides, amino acids
No Kreb's cycle
No respiratory ETC
What is a tertiary consequence of untreated syphillis if it becomes a CNS infection?
Gumma (gross ass lesions)
What surface exposed protein accounts for persistence of syphillis infection due to antigenic variation?
TprK
In order, what drugs does one use to treat syphillis?
1) Penicillin
2)Doxycycline, tetraycycline
3) Macrolides (but has high rates of resistance)