Pathology (final exam information)

Edema

presence of fluid in the body tissues
-either localized or generalized

Causes of Edema

-increased capillary permiability (inflammation)
-increased capillary pressure (hypertension)
-lymphatic obstruction
-hyporproteinemia (not enough protein)
-electrolyte imbalance
-liver disease
-kidney disease
-heart disease

Pitting edema

most severe edema
-if you press on tissue your displacing so much fluid causing an imprint in the skin

Ascites

presence of edema in abdominal cavity
-liver disease, kidney disease, pancreatic disease

Hydrothorax

presence of fluid in the chest cavity
-lung issues

Hydropericardium

fluid occumulation in the pericardium sac

Lymphedemia

interruption in the lymphatic system, occumulating in the extremities

Hydrocele

occumulation of fluid in the scrotum
-birth or result of injury

Hydrocephaly

occumulation of fluid in the brain (ventricals, sub dural space)
-inlarge the infants heads
-in an adult, increased intercranial pressure results to brain damage

anasarca

generalized edema, due to liver, kidney and heart disease

Hyperemia

increased amount of blood in a part of the body
-vasodilation
-increased arterial flow
-decreased venous return

Physiologic Hyperemia

an erection; blushing

Pathologic Hyperemia

congestion; cut

Active Hyperemia

arterial

Passive Hyperemia

venous (always pathological)

Ischemia

localized deficiency of the blood

Causes of ischemia

-thrombus/embolus
-arteriosclerosis
-external pressure
-failure of vasodilation when needed (neural) vessal is not recieving neurological stimulus to dilate

Transient ischemic attack

mini stroke, no lasting effects

Angina

temporary decrease blood flow to the heart, extreme chest pain (localized)

Loss of sensation (ischemic)

cross your legs for a certain amount of time

Thrombosis

process of clot formation
-Thrombis (actual clot name)
-are attached to vessal walls

Causes of Thrombi

-damage to vessels (disease)
-stasis of blood
-cardiac disorders (blood gets thicker)
-changes in blood composition
-sepsis

Location and consequences of Thrombi

-arterial blockage (dry gangrene)
-poor venous return
-cardiac: can kill you immediatly

Changes in Thrombi

-Lysis is desired
-Fibrinolysin
-Heprin
-Fragmentation is (trouble) traveling and get stuck somewhere causing lack of blood flow

Consequences of Thrombi

-ischemia
-passive hyperemia
-infarction: death of tissue
-gangrene

Embolus

anything that is moving through the bloodstream
-fragments of thrombi (most common)
-pyogenic Bacteria (sepsis)
-tumor cells
-parasites
-fat embolus
-gas/air
-foreign bodies (glass from car accident)

Thrombus vs Embolus

Thrombus stays stationary
Embolus can move anywhere

Hemorrhage (extravastation)

Per rhexis: vessal wall is interrupted
Per diapedesis: moving out of vascular system into tissue

Types of hemmorrhages

External: (evident, overt): leaving the body
Internal: (concealed, covert): staying in body going to the organ

Petechia

small pin point hemorrhages into skin or mucous membranes. associated with pressure (throwing up = eye) (birth = eye)

Ecchymosis

-bruise
-blunt force, larger area of bleeding into the skin

Purpura

larger areas of bleeding in the skin, in the site of injury
-hemophilia

Senile purpura

happens with elderly, because their skin is thinner, hyaline degeneration, capillary walls are thinner

Hematoma

swelling of blood, quite large
-excised and drained

Epistaxis

nose bleed

Hemoptysis

coughing up blood from the respiratory system

Hematemesis

throwing up blood, coming from the dygestive system

Melena

blood in the feces

Hematuria

blood in the urine

Menorrhgia

excessive bleeding during mentral period

Meterrhagia

excessive bleeding between menstral period

Shock

decreased blood pressure and decreased tissue perfusion (decreased blood to tissues)

Hypovolemic shock

decreased blood volume (burns, loss of fluid)

Cardiogenic shock

occurs as a result of a problem with the heart (heart attack)

Peripherial circulatory shock

issue with blood vessels staying dilated when they should (hearing back news)

Septic shock

gram positive infections

Anaphylactic Shock

severe allergic reaction

Signs and symptoms of shock

Hypotension: decreased blood pressure
Tachycardia: increased heart rate
Hypothermia: body temp falls
-increased persperation, pale, cool and clammy
Oliguria: decreased urine output
Polydypsia: decreased thirst

Facial expressions of shock

blank stare or extremely anxious

Behavior of shock

very still and weak or very agitated

Categories of shock

Primary
-mild, comes on immediatly, usually lasts a short time
Secondary
-serious, long term, takes time to develop

SIDS

unexpected death of a child less than a year old
-usually happens between 2 and 4 months
-no other health issues usually
-african and native american have 2 to 3 times more likely

Diagnosis of SIDS

-thorough death scene investigation
-autopsy
-personal and family history
-known as diagnosis of "exclusion

Effects on the family (SIDS)

-lacking of understanding
-shock at suddenness
-possible involvement of law officials

Continuing factors of SIDS

-Back to sleep reduces the risk by 50%
-exposure to smoke (during or after pregnancy)
-overheating
-bedding (no pillows, toys, light cover)

Maternal Risk factors

-younger moms
-frequent pregnancies (less than one year apart)
-little or no pre natal care
-internal smoking
-didnt gain much weight during pregnancy
-substance abuse issues
-history of SIDS

Infant risk factors

-males
-late fall or winter (overheating)
-ethnicity
-immature brain stem (regulation of breathing)
-siblings who died of SIDS
-premature babies

Abrasion

superficial grazing of the skin (has it scabbed over or wet) (if wet, use hair dryer to dry area)

Contusion

extravasation with blunt trauma (not going to come out) (cosmetize)

Laceration

splitting of the skin (suture)

Avulsion

tearing away of skin (or body part)

Asphyxia

lack of oxygen
-suffocation (obstruction of air passages)
-smothering (external)
-choking (solid in airway)
-gagging (fluid in airway)
-traumatic (damage to the chest wall "flail")
-strangulation (manual or by ligation)

Coroner

-elected for 2 to 4 years
-voting age and member in the political party
-living in county of service

Medical examiner

-physician (board certified)
-appointed until resigns

Manor of death

Homicide
Unknown
Medical misadventure
Accidental
Natural
Suicides

Death by gunshot

-Accidental (need an eye witness)
-Suicide (range, location, less than 3 ft away)
-Homicide (range, location, more than 3 ft away)

Thermal injuries

-electrocution
entry and exit wounds
electric marks : patecial hemorrhages that the electricity traveled

Heat exhaustion

very hot, sweating, flushed

Heat stroke

no longer perspiring, body temp keeps rising

How to cool off someone with heat exhaustion or stroke?

-fan
-room temp water
-do not use ice

Rule of nines

percentage of burned body
9% for each body area

Munchhausen

causes injury to themselves just to get attention from others

Munchhausen by proxy

making someone else ill to get attention (not intentionally trying to kill them)
-usually happens with young (20s) mothers to their children