Penicillin action
Inhibitor of bacterial cell wall peptidoglycan synthesis - blocks transpeptidation. Activates enzymes in cell wall that result in cell lysis.
This contains a beta lactam ring
Penicillin
How does staph aureus break down penicillin
It produces B-lactamases that break down the B-lactam ring and inactivate the drug.
Serious IgE-mediated reactions of penicillins
Anaphylaxis and bronchospasm
Non-IgE-mediated reaction caused by penicillins
Macular popular rash
Natural PCNs
PCN G (Bicillin) (IM, IV)
PCN V
This type of PCN has moderate to High resistance in population (high failure rate)
Natural PCNs
This type of PCN has excellent activity against
Treponema pallidum (syphillis)
B-hemolytic streptococci
N. Meningitidis
Gram-positive anaerobes
Natural PCNs
This type of PCN has Good activity against
S. Pneumoniae
Viridans streptococci
Natural PCN's
Penicillinase-resistant penicillins
Dicloxacillin (PO)
This type of PCN is mainly for skin infections
Dicloxacillin
This type of PCN is resistant to destruction by B-lactamases produced by staphylococci but without B-lactamase inhibitor.
Penicillinase-resistant PCNs
(Dicloxacillin)
These are less active than natural PCNs against nonstaphylococcal gram-positive bacteria.
Penicillinase-resistant penicillins
This type of PCN has excellent activity against Staph Aureus
Dicloxacillin
This PCN has good activity against streptococci
Dicloxacillin
Extended-spectrum PCNs
Amoxicillin (PO)
Ampicillin (PO/IV)
Of the extended-spectrum PCNs, which is the best choice for oral treatment of infection?
Amoxicillin due to improved bioavailability and less frequent dosage frequency.
What type of PCN has excellent activity against
B-hemolytic streptococci
E. Faecalis
Extended-spectrum
What type of PCN has good activity against
S. Pneumoniae
viridans streptococci
H. Influenzae
Extended-spectrum PCN
What type of PCN is more likely to cause a rash?
Extended-spectrum
Aminopenicillin/ B-lactamase inhibitors
Amoxicillin/clavulanate (Augmentin)(PO)
Ampicillin/sulbactam (Unasyn)(IV)
This type of PCN is most commonly associated with diarrhea
Aminopenicillin/B-lactamase inhibitors
B-lactamase inhibitors effectively inactivate B-lactamases produced by what organisms?
S. Aureus
H. Influenzae
Moraxella catarrhalis
B fragilis
This PCN has the activity of Amoxicillin and ampicillin plus excellent activity against
H. Influenzae
Bacteriodes fragilis
Proteus
Aminopenicillin/B-lactamase inhibitors
The Aminopenicillin/B-lactamase inhibitors have good activity against what organisms?
E. coli
Klebsiella
Staph Aureus
Antipseudomonal penicillins
Piperacillin/tazobactam (Zosyn) (IV)
This type of PCN has the activity of ampicillin/sulbactam plus excellent activity against
E. Coli
Klebsiella
Piperacillin/tazobactam (Zosyn) (IV)
Antipseudomonal PCNs have good activity against what organisms?
Pseudomonas
Citrobacter
Enterobacter
Penicillin action
Inhibitor of bacterial cell wall peptidoglycan synthesis - blocks transpeptidation. Activates enzymes in cell wall that result in cell lysis.
This contains a beta lactam ring
Penicillin
How does staph aureus break down penicillin
It produces B-lactamases that break down the B-lactam ring and inactivate the drug.
Serious IgE-mediated reactions of penicillins
Anaphylaxis and bronchospasm
Non-IgE-mediated reaction caused by penicillins
Macular popular rash
Natural PCNs
PCN G (Bicillin) (IM, IV)
PCN V
This type of PCN has moderate to High resistance in population (high failure rate)
Natural PCNs
This type of PCN has excellent activity against
Treponema pallidum (syphillis)
B-hemolytic streptococci
N. Meningitidis
Gram-positive anaerobes
Natural PCNs
This type of PCN has Good activity against
S. Pneumoniae
Viridans streptococci
Natural PCN's
Penicillinase-resistant penicillins
Dicloxacillin (PO)
This type of PCN is mainly for skin infections
Dicloxacillin
This type of PCN is resistant to destruction by B-lactamases produced by staphylococci but without B-lactamase inhibitor.
Penicillinase-resistant PCNs
(Dicloxacillin)
These are less active than natural PCNs against nonstaphylococcal gram-positive bacteria.
Penicillinase-resistant penicillins
This type of PCN has excellent activity against Staph Aureus
Dicloxacillin
This PCN has good activity against streptococci
Dicloxacillin
Extended-spectrum PCNs
Amoxicillin (PO)
Ampicillin (PO/IV)
Of the extended-spectrum PCNs, which is the best choice for oral treatment of infection?
Amoxicillin due to improved bioavailability and less frequent dosage frequency.
What type of PCN has excellent activity against
B-hemolytic streptococci
E. Faecalis
Extended-spectrum
What type of PCN has good activity against
S. Pneumoniae
viridans streptococci
H. Influenzae
Extended-spectrum PCN
What type of PCN is more likely to cause a rash?
Extended-spectrum
Aminopenicillin/ B-lactamase inhibitors
Amoxicillin/clavulanate (Augmentin)(PO)
Ampicillin/sulbactam (Unasyn)(IV)
This type of PCN is most commonly associated with diarrhea
Aminopenicillin/B-lactamase inhibitors
B-lactamase inhibitors effectively inactivate B-lactamases produced by what organisms?
S. Aureus
H. Influenzae
Moraxella catarrhalis
B fragilis
This PCN has the activity of Amoxicillin and ampicillin plus excellent activity against
H. Influenzae
Bacteriodes fragilis
Proteus
Aminopenicillin/B-lactamase inhibitors
The Aminopenicillin/B-lactamase inhibitors have good activity against what organisms?
E. coli
Klebsiella
Staph Aureus
Antipseudomonal penicillins
Piperacillin/tazobactam (Zosyn) (IV)
This type of PCN has the activity of ampicillin/sulbactam plus excellent activity against
E. Coli
Klebsiella
Piperacillin/tazobactam (Zosyn) (IV)
Antipseudomonal PCNs have good activity against what organisms?
Pseudomonas
Citrobacter
Enterobacter