Cefazolin (Ancef)
-Dose: 1-2g or 10-15 mg/kg
-Redose: q4h
-Administration: IVP
-Note: 5-10% cross reaction with PCN allergy
-Class: Generation 1 Cephalosporin
-MOA: Interferes with peptidoglycan synthesis of bacterial cell walls
Cefoxitin
-Dose: 2g
-Redose: q3h
-Administration: IVP
-Class: Generation 2 Cephalosporin (greater Gram Negative activity)
-MOA: Interferes with peptidoglycan synthesis of bacterial cell walls
Indications: GI and GYN/OB
Ampicillin / Sulbactam
-Dose: 3g
-Redose: q3h
-Administration: Over 30 mins
-Note: Penicillinase-susceptible
-Class: 2nd Generation Penicillin
-MOA: Interferes with peptidoglycan synthesis of bacterial cell walls (acts on beta-lactam ring)
Clindamycin
-Dose: 600-900mg
-Redose: q8h
-Administration: Over 30 min
-Note: High incidence of diarrhea
-MOA: Inhibits bacterial protein synthesis
Indications:
-GI Tract Infection
-S. aureus bone infection
-PCN allergy patients
Gentamicin
-Dose: 1.5 mg/kg (Or 80mg IVP)
-Redose: None
-Administration: Over 30 mins
-Notes:
--Prolongs NDMR
--Ototoxicity
--Nephrotoxicity
--Skeletal Muscle Weakness
-MOA: Disruption of Protein Synthesis in Bacteria
-Class: Aminoglycoside
-Indications: Opthalmic s
Vancomycin
-Dose: 1-1.5 g / 2g (or 15mg/kg)
-Redose: q8h
-Administration: Infuse over 1hr (2hrs before incision)
-Note: Red Man Syndrome
-MOA: Impairs cell wall synthesis (Gram + Bacteria)
-Class: Glycopeptide
-Indications:
--last line of treatment for MRSA
--Cephal
Metronidazole (Flagyl)
-Dose: 500mg
-Redose: q8h or q12h
-Administration: Infuse over 30 mins
-Note: N/V
-MOA: Destruction of bacterial DNA helical structure
Indications
-rosacea
-bone and joint infection
-abdominal and pelvic sepsis
-endocarditis
-elective colorectal surgery
Ciprofloxacin (Ciproxin)
-Dose: 400mg
-Redose: q12h
-Administration: Infuse over 20 mins (2hrs before incision)
-Class: Flouroquinoline
Indications:
-Urinary tract infection
-Bacterial Gastroenteritis
-External Otitis
Tetracycline
-MOA Inhibition of bacterial cell tRNA translation
-Phototoxicity
Erythromycin
Macrolide
MOA - inhibition of protein synthesis
-Inhibits P450 system in the liver and will cause prolonged duration of certain drugs
-Indications:
--Bronchitis, pneumonia