What is the generic for Xarelto?
Rivaroxaban
What is the generic for Coumadin?
Warfarin
What is the generic for Jantoven?
Warfarin
What is the brand name for Clopidogrel?
Plavix
What is the brand name for Dabigatran Etexilate Mesylate?
Pradaxa
What is the generic for Nascobal?
Cyanocobalamin (Vitamin B12)
What is the generic for Aggrenox?
Dipyridamole with Aspirin
What is the brand name for Apixaban?
Eliquis
What is the drug class of Rivaroxaban (Xarelto)?
Anticoagulant
What is the drug class of Warfarin?
Anticoagulant
What is the drug class of Clopidogrel (Plavix)?
Hematological Agent
What is the drug class of Dabigatran (Pradaxa)?
Hematological Agent
What is the drug class of Cyanocobalamin (Nascobal)?
Hematological Agent
What is the drug class of Aggrenox?
Antiplatelet Agent
What is the drug class of Apixaban (Eliquis)?
Hematological Agent
Which drug comes in tablets and powder for injection, lyophilized?
Warfarin
Which drug comes in intranasal gel, sublingual tablets, and solution for injection?
Cyanocobalamin (Vitamin B12)
Which drug comes in 75 mg and 300 mg tablets?
Clopidegrel (Plavix)
How many mcg are in each activation of intranasal gel Cyanocobalamin?
500 mcg
Which drug comes in an OTC form?
Cyanocobalamin (Vitamin B12)
How much of each ingredient (Dipyridamole and Aspirin) is in an Aggrenox capsule?
200 mg Dipyridamole
25 mg Aspirin
Which drug only comes in 2.5 mg and 5 mg tablets?
Apixaban (Eliquis)
Which drugs are indicated for treatment and prophylaxis for venous thrombosis?
Warfarin
Xarelto
Eliquis
Which drug is indicated for prophylaxis and treatment of pulmonary embolism?
Warfarin
Which drug is indicated for the reduction of atherosclerotic events (MI, stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent MI, or established Peripheral Aterial disease (PAD)?
Plavix
Which drug is indicated to reduce the risk of stroke in patients who have had transient ischemia of the brain or completed ischemic stroke due to thrombosis?
Aggrenox (Dipyridamole with Aspirin)
Which drug is indicated for maintenance of normal hematological status in pernicious anemia patients (associated with folic acid deficiency, fish tapeworm infestation, total gastrectomy, pancreas or bowel malignancies)?
Cyanocobalamin (Vitamin B12)
Which drug is usually supplemented with folic acid?
Cyanocobalamin (Vitamin B12)
Which drug is indicated for the reduction of atherosclerotic events in patients with acute coronary syndrome including unstable angina and non-Q-wave myocardial infarction?
Plavix
When using Plavix for the reduction of atherosclerotic events in patients with acute coronary syndrome, what other drug and dose should be used in conjunction?
Aspirin (75 mg-325 mg)
*Most patients will also be treated acutely with Heparin.
Which drug should be taken with food?
Rivaroxaban (Xarelto)
When changing to a parenteral anticoagulant, one should wait how long after the last dose of Pradaxa?
12 hours (CrC>30 ml/min)
or
24 hours (CrCl 15-30 min)
When changing from Warfarin to Pradaxa, one should wait till the INR reaches below what level?
2.0
When changing from Pradaxa to Warfarin, the patient should start Warfarin before stopping Pradaxa for how many days?
3 days: CrCl >50 ml/min
2 days: CrCl 30-50 ml/min
1 day: CrCl 15-30 ml/min
Which enzyme converts Clopidogrel to its active metabolite?
CYP2C19
Which drug's active metabolite inhibits platelet aggregation by irreversibly modifying platelet receptors thereby selectively inhibiting the binding of aadenosine diphosphate (ADP) to the receptor, which inhibits the activation of the glycoprotein GPIIb/I
Clopidogrel (Plavix)
Which drug inhibits platelet aggregation in response to platelet activation factor (PAF), collagen and adenosine diphosophate (ADP) by inhibiting the uptake of adenosine into platelets causing a stimulation of platelet adenylate cyclase and subsequent inc
Dipyridamole
Which drug inhibits prostaglandin and thromboxane A2 synthesis by acetylating the enzyme cyclooxygenase?
Aspirin
Which drug antagonizes vitamin K resulting in a decreased hepatic synthesis of vitamin K-dependent clotting factors (II, VII, IX, and X)?
Warfarin
What are the vitamin K-dependent clotting factors inhibited by Warfarin?
II
VII
IX
X
What drug and its metabolites are competitive, direct thrombin inhibitors?
Dabigatran Etexilate Mesylate (Pradaxa)
Which drugs are selective inhibitors of Factor Xa?
Apixaban (Eliquis)
Rivaroxaban (Xarelto)
Which enzyme metabolizes Eliquis?
CYP3A4
What is the first sign of Vitamin B12 or folic acid deficiency?
Megaloblastic anemia
Which drug inhibits the CYP2C9 enzyme?
Clopidogrel (Plavix)
Which drug has been reported to rarely cause thrombotic thrombocytopenic purpura (TTP)?
Clopidogrel (Plavix)
What is the Pregnancy Category of Clopidogrel?
Category B
Which drug is contraindicated in patients with early Leber's disease (hereditary optic nerve atrophy)?
Cyanocobalamin (Vitamin B12)
Which drug has anaphylactic shock as a risk with the initiation of parenteral therapy, so the first dose should be given in a clinic setting?
Cyanocobalamin (Vitamin B12)
Which drug should be stopped at least 18 hours before removing an epidural catheter and not started therapy within 6 hours after removal?
Rivaroxaban (Xarelto)
Which drug is Pregnancy Category X?
Warfarin
Which drug is contraindicated in patients with inadequate mental state, spinal puncture, lumbar block anesthesia and in patients with malignant hypertension?
Warfarin
Which drug should be used with caution in patients with severe diabetes, and congestive heart failure?
Warfarin
Which drug is contraindicated in patients with the syndrome of asthma, rhinitis, and nasal polyps?
Dipyridamole with Aspirin (Aggrenox)
Which drug is Pregnancy Category D in the third trimester?
Dipyridamole with Aspirin (Aggrenox)
Which drug has alopecia, fever, and dermatitis as adverse effects?
Warfarin
Which drug has contusion, hematoma, and gingival bleeding as adverse effects?
Apaxaban (Eliquis)
Which drug has upper respiratory tract infection (8.7%), chest pain (8.3%), head ache (7.6%), flu-like symptoms (7.5%), arthralgia (6.3%), dizziness (6.2%) back pain (5.8%) coughing, and depression as adverse effects?
Clopidogrel (Plavix)