LT3 - Drugs for STD in Women

Ceftriaxone + Azithromycin/Doxycycline

Treatment for cervical dishcarge

Gonorrhea + Chlamydia

Most presumptive diagnoses for cervical discharge

PCR or other NAAT

Diagnostic test for Chlamydia

Azithromycin/Doxycycline

CDC recommended treatment for uncomplicated genital chlamyidal infections

Azithromycin/Amoxicillin

CDC recommended treatment for complicated/Pregnant women chlamydia

GI upset

One of the significant side effect of macrolides

Inhibition of 50S subunit

MOA of macrolides

Inhibition of 30S subunit

MOA of tetracyclines

broad spec with atypical bacteria

both macrolides and tetracyclines are indicated for these infections

bone deposition

main side effect of doxycycline

inhibits DNA gyrase Topo II and Topo IV

MOA of fluoroquinolones

cell wall synthesis inhibitor

MOA of amoxicillin

gram + and gram - bacteria with h. influenzae

Indication for Amoxicillin

Hypersensitivity, SJS

Main side effect of amoxicillin

Microscopy, culture, PCR and other NAAT

Diagnostic tests for Gonorrhea

Ceftriaxone + Azithromycin/Doxycline

Recommended treatment for uncomplicated gonococcal infections of the Cervix, Urethra, Rectum. 1st is for gonorrhea and 2nd is for chlamydia

Quinolones

No longer recommended for treatment of gonorrhea and associated conditions such as PID

Cefixime

If ceftriaxone is not available you used this for gonorrhea

Gardnerella vaginalis and Mobiluncus

Bacterial vaginosis most common agents (2)

Microscopy - gram stain

Diagnostic test for Bacterial vaginosis

Metronidazole or clindamycin

Treatment for bacteria vaginosis

Inhibition of nucleic acid sythesis

MOA of metronidazole

Inhibition of 50S

MOA of clindamycin

Pseudomembranous colitis

Adverse effect of clindamycin

Anaerobes, and gram+ aerobes

Indications of clindamycin

Anaerobic bacteria

indications for metronidazole

Azoles or Nystatin

Treatment for Candidiasis

Reduces ergosterol synthesis

MOA of Azoles

Increases cell membrane permeablity by binding to membrane ergosterols

MOA of nystatin

Broad spec antifungal for amphotericin resistant infections

Indication for azoles

Topical infection of candida

Indication for nystatin

Metronidazole or Tinidazole

Treatment for Trichomoniasis

Diamond's medium

Gold standard for diagnosis of trichomoniasis

Amoebiasis

Indication for Tinidazole

Benzathine penicillin

Recommended treatment for syphillitic Chancre

Jarisch-Herxheimer reaction

What can happen with administration of penicillin for syphilis?

Transpeptidation of cell wall synthesis

MOA of benzathine penicillin

Gram +, Gram- cocci, non-B lactamase anaerobes

Indication of Benzathine penicillin

Azithromycin or ceftriaxone or ciprofloxacin(x preg) or erythromycin

Treatment for Chancroid by H. ducreyi

C. trachomatis

Agent for Lymphogranuloma venerum

Doxycline or Erythromycine

Treatment for LGV

K. granulomatis

Agent of granuloma inguinale

Pseudobobo (subq granulomas)

Defining feature of granuloma inguinale

Donovan bodies in darkfield microscopy

Diagnosis of granuloma inguinale

Azithromycin or Doxy or Cipro or Erythro or TMP-SMX

Treatment for granuloma inguinale

Folate antagonist, blocks purine production and nucleic acid synthesis

MOA of TMP-SMX

UTI, nocardiosis, toxoplasmosis, P jiroveci

Indications for MOA of TMP-SMX

Acyclovir or Valacyclovir or Famciclovir

Treatment of HSV

Inhibits DNA polymerase

MOA of Acyclovir

Podofilox or imiquimod or podophyllin resin

Treatment of Papillomavirus

Ceftriaxone + Doxycycline

Recommended treatment for epididymitis

Levofloxacin or ofloxacin

Acute epididymitis treatment caused by enteric organisms