Ceftriaxone + Azithromycin/Doxycycline
Treatment for cervical dishcarge
Gonorrhea + Chlamydia
Most presumptive diagnoses for cervical discharge
PCR or other NAAT
Diagnostic test for Chlamydia
Azithromycin/Doxycycline
CDC recommended treatment for uncomplicated genital chlamyidal infections
Azithromycin/Amoxicillin
CDC recommended treatment for complicated/Pregnant women chlamydia
GI upset
One of the significant side effect of macrolides
Inhibition of 50S subunit
MOA of macrolides
Inhibition of 30S subunit
MOA of tetracyclines
broad spec with atypical bacteria
both macrolides and tetracyclines are indicated for these infections
bone deposition
main side effect of doxycycline
inhibits DNA gyrase Topo II and Topo IV
MOA of fluoroquinolones
cell wall synthesis inhibitor
MOA of amoxicillin
gram + and gram - bacteria with h. influenzae
Indication for Amoxicillin
Hypersensitivity, SJS
Main side effect of amoxicillin
Microscopy, culture, PCR and other NAAT
Diagnostic tests for Gonorrhea
Ceftriaxone + Azithromycin/Doxycline
Recommended treatment for uncomplicated gonococcal infections of the Cervix, Urethra, Rectum. 1st is for gonorrhea and 2nd is for chlamydia
Quinolones
No longer recommended for treatment of gonorrhea and associated conditions such as PID
Cefixime
If ceftriaxone is not available you used this for gonorrhea
Gardnerella vaginalis and Mobiluncus
Bacterial vaginosis most common agents (2)
Microscopy - gram stain
Diagnostic test for Bacterial vaginosis
Metronidazole or clindamycin
Treatment for bacteria vaginosis
Inhibition of nucleic acid sythesis
MOA of metronidazole
Inhibition of 50S
MOA of clindamycin
Pseudomembranous colitis
Adverse effect of clindamycin
Anaerobes, and gram+ aerobes
Indications of clindamycin
Anaerobic bacteria
indications for metronidazole
Azoles or Nystatin
Treatment for Candidiasis
Reduces ergosterol synthesis
MOA of Azoles
Increases cell membrane permeablity by binding to membrane ergosterols
MOA of nystatin
Broad spec antifungal for amphotericin resistant infections
Indication for azoles
Topical infection of candida
Indication for nystatin
Metronidazole or Tinidazole
Treatment for Trichomoniasis
Diamond's medium
Gold standard for diagnosis of trichomoniasis
Amoebiasis
Indication for Tinidazole
Benzathine penicillin
Recommended treatment for syphillitic Chancre
Jarisch-Herxheimer reaction
What can happen with administration of penicillin for syphilis?
Transpeptidation of cell wall synthesis
MOA of benzathine penicillin
Gram +, Gram- cocci, non-B lactamase anaerobes
Indication of Benzathine penicillin
Azithromycin or ceftriaxone or ciprofloxacin(x preg) or erythromycin
Treatment for Chancroid by H. ducreyi
C. trachomatis
Agent for Lymphogranuloma venerum
Doxycline or Erythromycine
Treatment for LGV
K. granulomatis
Agent of granuloma inguinale
Pseudobobo (subq granulomas)
Defining feature of granuloma inguinale
Donovan bodies in darkfield microscopy
Diagnosis of granuloma inguinale
Azithromycin or Doxy or Cipro or Erythro or TMP-SMX
Treatment for granuloma inguinale
Folate antagonist, blocks purine production and nucleic acid synthesis
MOA of TMP-SMX
UTI, nocardiosis, toxoplasmosis, P jiroveci
Indications for MOA of TMP-SMX
Acyclovir or Valacyclovir or Famciclovir
Treatment of HSV
Inhibits DNA polymerase
MOA of Acyclovir
Podofilox or imiquimod or podophyllin resin
Treatment of Papillomavirus
Ceftriaxone + Doxycycline
Recommended treatment for epididymitis
Levofloxacin or ofloxacin
Acute epididymitis treatment caused by enteric organisms