What is the role of Phosphodieterase in men's health?
Secreted to counteract vasodilation
What is the mechanism of action for sexual dysfunction of a male?
cGMP - vasodilation - corpus cavernosum - phosphodieterase
What drugs cause sexual dysfunction in a male?
Antidepressants
Antihistamines
Antihypertensives
Antiulcer
Sedatives and recreational drugs
What physiological disorders affect men's sexual health?
Diabetes mellitus
Coronary artery disease
Vascular disease
Sildenafil citrate
Viagra
Sildenaful citrate onset
30-60 minutes
Sildenaful citrate duration
4 hours
Vardenaful
Levitra
Vardenaful onset
25-30 minutes
Vardenaful duration
4-5 hours
Tadalafil
Cialis
Tadalafil onset
15-60 minutes
Tadalafil duration
24-36 hours
Avanafil
Stendra
Avanafil onset
15-60 minutes
Avanafil duration
24-36 hours
Side effects of men's sexual dysfunction medications
Headache
Dyspnea
Dizziness
Vision changes
Painful/cloudy urination
What is important for the patient to avoid when taking men's sexual dysfunction medication?
No nitrates because it also causes vasodilation leading to hypotension
5-alpha reductase inhibitors
Inhibits an enzyme in the prostate which causes decreased prostate growth
How long does it take for 5-alpha reductase inhibitors to work?
Up to 6 months
Who cannot handle 5-alpha reductase inhibitors?
Pregnant women because there is a risk of absorption through skin that could affect fetus
What cancer does 5 alpha reductase inhibitors increase the risk of developing?
Prostate
Finasteride
Proscar
5-alpha reductase inhibitor
Duastride
Avodart
5-alpha reductase inhibitor
Alpha- adrenergic blocking agents
Causes vasodilation within urethra to open space and vasoconstrictor prostate so man can pass more urine through the urethra
What is a significant risk of Alpha-adrenergic blocking agents?
Hypotension (especially orthostatic hypotension)
What patient education is needed for alpha adrenergic blocking agents?
Slowly sit/stand up
If encountering dizziness/lightheadedness- need to sit down
First dose effect and alpha adrenergic blocking agents
Risk of hypotension, especially after first dose, patient needs to be monitored frequently with BP
What are safety precautions for alpha adrenergic blocking agents?
Use call bell, don't get up without assistance
Tamsulosin
Flomax
Alpha adrenergic blocking agent
Doxazosin
Cardura
Alpha adrenergic blocking agent
Terasozin
Hytrin
Alpha adrenergic blocking agent