what is an idiosyncratic reaction?
genetically related abnormal response to a chemical (extremely sensitive or insensitive)
Idiosyncratic rxn: Phenylbutazone toxicity
aplastic anemia
Idiosyncratic rxn: Phenylbutazone mechanism
oxidation by peroxidases
Idiosyncratic rxn: Fenbendazole toxicity
pancytopenia, bone marrow necrosis
Idiosyncratic rxn: fenbendazole mechanism
onset within 2 weeks
Idiosyncratic rxn: Flucytosine toxicity
skin eruptions, depigmentation and ulcerations
Idiosyncratic rxn: Flucytosine mechanism
onset after 2-6 wks, mucocutaneous junctions
Idiosyncratic rxn: Mitotane toxicity
hepatopathy, bone marrow necrosis
Idiosyncratic rxn: Mitotane mechanism
seen after 1 month
Idiosyncratic rxn: Griseofulvine toxicity
pancytopenia (or neutropenia in cats)
Idiosyncratic rxn: Griseofulvine mechanism
neutropenia in FIV cats
Idiosyncratic rxn: Albendazole toxicity
bone marrow suppression in one cat
Idiosyncratic rxn: Albendazole mechanism
mechanism unknown
Idiosyncratic rxn: Meloxicam toxicity
vasculitis with ulcers, vesicles and erosions
Idiosyncratic rxn: Meloxicam mechanism
within 2 days
Idiosyncratic rxn: Sulphonamides toxicity
hepatopathy, blood dyscrasia, skin eruptions
Idiosyncratic rxn: Sulphonamides mechanism
Oxidised hydroxl amine metabolite (CYP450, MPO)
Idiosyncratic rxn: Methimazole toxicity
hepatopathy, blood dyscrasia, skin eruptions
Idiosyncratic rxn: Methimazole mechanism
N-methylthioura metabolite (FMO) - antibodies