aripiprazole (Abilify)
drug class: antipsychoticMOA: partial agonist at D2 receptors. Lowering dopaminergic neurotransmission in the mesolimbic pathway.
isotretinoin (absorica)
class: retinoids (effective acne therapy)MOA: inhibits sebaceous gland function and keratinization at pharmacologic doses
zafirlukast (accolate)
class: leukotriene receptor antagonistsMOA: blocks the action of the cysteinyl leukotrienes on the CysLT1 receptors, thus reducing constriction of the airways, build-up of mucus in the lungs and inflammation of the breathing passages.
quinapril (accupril)
class: angiotensin-converting enzyme (ACE) inhibitors.MOA: it's deesterified to the principal metabolite, quinaprilat, which is an inhibitor of ACE activity in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor, angiotensin II.
tetracycline (achromycin)
class: tetracyclines (bacteriostatic)MOA: block protein synthesis binding to 30S ribosomal subunit. blocks t-RNA binding to the A site which prevents addition of amino acids to growing peptide
rabeprazole (aciphex)
class: proton pump inhibitor (PPI)MOA: inhibit proton pumps that are actively secreting (suppresses acid secretion by inhibiting parietal cell H+/K+ ATPase pumps)
omeprazole (prilosec)
class: proton pump inhibitor (PPI)MOA: inhibit proton pumps that are actively secreting (suppresses acid secretion by inhibiting parietal cell H+/K+ ATPase pumps)
lansoprazole (prevacid)
class: proton pump inhibitor (PPI)MOA: inhibit proton pumps that are actively secreting (suppresses acid secretion by inhibiting parietal cell H+/K+ ATPase pumps)
esomeprazole (nexium)
class: proton pump inhibitor (PPI)MOA: inhibit proton pumps that are actively secreting (suppresses acid secretion by inhibiting parietal cell H+/K+ ATPase pumps)
doxycycline (Doryx)
class: tetracyclines (bacteriostatic)MOA: block protein synthesis binding to 30S ribosomal subunit. blocks t-RNA binding to the A site which prevents addition of amino acids to growing peptide
gentamicin (garamycin) (genoptic)
class: aminoglycosides. aerobic gram (-) MOA: irreversible inhibition of initiation complex through binding of 30S subunit. cause misreading of the code mRNA template. inhibit translocation
amikacin (amikin)
class: aminoglycosides. aerobic gram (-). bactericidal.MOA: irreversible inhibition of initiation complex through binding of 30S subunit. cause misreading of the code mRNA template. inhibit translocation
tobramycin (tobrex)
class: aminoglycosides. aerobic gram (-). bactericidalMOA: irreversible inhibition of initiation complex through binding of 30S subunit. cause misreading of the code mRNA template. inhibit translocation
erythromycin (Ilotycin)
class: macrolides (bacteriostatic). gram (+)MOA: block protein synthesis by binding to 50S ribosomal subunit. inhibit aminoacyl translocation reaction*strongly inhibits CYP3A4*
azithromycin (Z-PAK) or (Zithromax) or (AzaSite)
class: macrolides (bacteriostatic). gram (+)MOA: block protein synthesis by binding to 50S ribosomal subunit. inhibit aminoacyl translocation reaction
clindamycin (cleocin)
class: other protein synthesis inhibitorsMOA: binds to 50S subunit at same site as macrolides & inhibits aminoacyl translocation reaction