a1 location
smooth muscle
a1 g protein
Gq
a1 mechanism
Increase in IP3 and Ca2+
a2 location
GI tract
a2 G protein
Gi
a2 mechanism
decrease cAMP
B1 location
heart
B1 G protein
Gs
B1 mechanism
increase cAMP
B2 location
smooth muscle
B2 G protein
Gs
B2 mechanism
increase cAMP
adrenergic receptors
a1, a2, B1, B2, B3
Cholinergic receptors
Nm(N1), Nn(N2), M1, M2, M3
Nm location
skeletal muscle
Nm mechanism
opening Na+/K+ channels
Nn location
autonomic ganglia
Nm mechanism
opening Na+/K+ channels
M1 location
CNS
M1 G protein
Gq
M1 mechanism
Increase in IP3 and Ca2+
M2 location
heart
M2 G protein
Gi
M2 mechanism
decrease cAMP
M3 location
glands, smooth muscle
M3 G protein
Gq
M3 mechanism
Increase in IP3 and Ca2+
a1 receptor agonist and antagonist
agonist: norepi and phenylepherineantagonist: prazosin
b1 receptor agonist and antagonist
agonist: norepi, isoproterenolantagonist: propranolol, metoprolol
nicotinic agonist and antagonist
agonist: ach, nicotineAntagonist: curare
muscarinic receptor agonist and antagonist
agonist: achantagonist: atropine
B2 receptor agonist and antagonist
agonist: albuterolantagonist: propranolol