ACEi
CI w/ pregnancy, bilateral renal artery stenosis, renal failureFirst-line for CKDADE = ↑ K+, metabolic acidosis, cough, angioedema [especially AA]DDI = NSAIDDFI = licorice [↑ BP/Na+/H2O, ↓ K+]
trandolapril
Mavik 4mg
ramipril
Altace 10mg
moexipril
Univasc 30mg
quinapril
Accupril 40mg
lisinopril
Prinivil, Zestril, Qbrelis [suspension] 40mg
benazepril
Lotensin 40mg
enalapril
Vasotec, Enalaprilat [IV] 40mg
fosinopril
monopril 40mg
captopril
Capoten 50mg TID
trandolapril + verapamil
Tarka
quinapril + HCTZ
Accuretic, Quinaretic
lisinopril + HCTZ
Zestoretic, Prinzide
benazepril + HCTZ
Lotensin HCT
enalapril + HCTZ
Vaseretic
ARBs
CI w/ pregnancy, bilateral renal artery stenosis, renal failureACEi + ARBs combination possible w/ HFADE = ↑ K+, metabolic acidosis, less cough + angioedema [compared to ACEi]DDI = NSAIDDFI = licorice [↑ BP/Na+/H2O, ↓ K+]
candesartan
Atacand 32mg
olmesartan
Benicar 40mg
azilsartan
Edarbi 80mg
telmisartan
Micardis 80mg
losartan
Cozaar 100mg
irbesartan
Avapro 300mg
valsartan
Diovan 320mg
eprosartan
Teveten 800mg
olmesartan + HCTZ
Benicar HCT
telmisartan + HCTZ
Micardis HCT
losartan + HCTZ
Hyzaar
irbesartan + HCTZ
Avalide
valsartan + HCTZ
Diovan HCT
aliskiren + HCTZ
Tekturna HCT 300mg
aliskiren + valsartan
Valturna 300mg
thiazide diuretics
CI w/ sulfa allergyDiuretic of choice w/o renal impairmentADE = ↑ Ca2+/BG/TG/cholesterol, ↓ K+/Na+/Mg2+, metabolic alkalosis, photosensitivity/rashDDI = lithium [↑ lithium toxicity]
indapamide
Lozol 2.5mg
metolazone
Zaroxolyn 20mg
chlorthalidone
Thalitone 25mg
hydrochlorothiazide
Microzide 50mg
chlorothiazide
Diuril 500mg
chlorthalidone + azilsartan
Edarbyclor
chlorthalidone + atenolol
Tenoretic
HCTZ + triamterene
Maxzide, Dyazide
HCTZ + spironolactone
Aldactazide
loop diuretics
CI w/ sulfa allergy [except Edecrin]Diuretic of choice w/ renal disease, HF [↓ edema]ADE = ↑ BG/TG/cholesterol, ↓ Ca2+/K+/Na+/Mg2+, metabolic alkalosis, photosensitivity/rash, ototoxicityDDI = lithium [↑ lithium toxicity], Edecrin w/ aminoglycosidesbumetanide 1mg = torsemide 20mg = furosemide 40mg = ethacrynic acid 50mg [PO]
bumetanide
Bumex 1mg BID
torsemide
Demadex 10mg QD
furosemide
Lasix 40mg BID
ethacrynic acid
Edecrin 25-50mg QD
K+-sparing diuretics
CI w/ CrCl < 30ADE = ↑ K+, metabolic acidosis, ↓ Ca2+
triamterene
Dyrenium 300mg
amiloride
Midamor 20mg
aldosterone receptor antagonists
CI w/ pregnancy, CrCl < 30For HTN, HFADE = ↑ K+, metabolic acidosis, ↓ Ca2+, gynecomastia [spironolactone]
spironolactone
Aldactone, Carospir 25-50mg w/ food
eplerenone
Inspra 25-50mg
beta-blockers
CI w/ heart block, severe bradycardia [<60 bpm]First-line for post-MI, SIHDADE = fatigue, depression, weight gain, fluid retention, dyslipidemia, ↓ libidoNon-selective = carteolol, timolol, pindolol, propranolol, penbutolol, nadololNon-selective w/ alpha-1 block = carvedilol, labetalolSelective beta-1 block = atenolol, metoprolol, esmolol, bisoprolol, betaxolol, acebutolol ["AMEBBA"]Selective beta-1 block w/ NO vasodilation = nebivolol
carteolol
Cartrol 10mgOcupress for glaucoma
timolol
Blocadaren 40mg BID Timoptic for glaucoma
pindolol
Visken 40mg BID
propranolol
Inderal, InnoPran 40mg BID or 80mg
penbutolol
Levatol 80mg
nadolol
Corgard 320mg
carvedilol
Coreg 50mg BID or 80mg
labetalol
Normodyne, Trandate 800mg BID
bisoprolol
Zebeta 10mg
metoprolol
Lopressor, Toprol 25-200mg HTN = 400mgHF = 200mg
Betaxolol
Kerlone 40mgBetoptic for glaucoma
atenolol
Tenormin 100mg
acebutolol
Sectral 400mg BID
esmolol
Brevibloc [IV] for HTN emergency
nebivolol
Bystolic 40mg
bisoprolol + HCTZ
Ziac
metoprolol tartrate + HCTZ
Lopressor HCT
metoprolol succinate + HCTZ
Dutoprol
beta-blockers for glaucoma
Non-selective = carteolol [Ocupress], timolol [Timoptic]Selective beta-1 block = betaxolol [Betoptic]
CCBs
CI w/ HF + heart block for non-DHP CCBs [diltiazem, verapamil], MI for DHP-CCBs [amlodipine, felodipine, isradipine, nisoldipine, nicardipine, nifedipine]Non-DHP CCBs for CKD, diabetic nephropathy, arrhythmia [negative inotrope]ADE = gingival hyperplasia, constipation, bradycardia, flushing + edema [DHP-CCBs]DDI = CYP3A4
diltiazem
Cardizem, Tiazac 120mg divided QD, BID, TID
verapamil
Calan, Verelan, Covera, Isoptin 120mg divided QD, BID, TIDCovera → ghost tablet
amlodipine
Norvasc, Katerzia [suspension] 10mg
felodipine
Plendil 10mg
isradipine
Dynacirc 10mg
nisoldipine
Sular 34mg → ghost tablet
nicardipine
Cardene 60mg BID or TID
nifedepine
Adalat, Procardia 90mgAdalat → ghost tablet
amlodipine + perindopril
Prestalia
amlodipine + benazepril
Lotrel
amlodipine + olmesartan
Azor
amlodipine + olmesartan + HCTZ
Tribenzor
amlodipine + telmisartan
Twynsta
amlodipine + valsartan
Exforge
amlodipine + valsartan + HCTZ
Exforge HCT
alpha-1 blockers
Third-line for HTNADE = syncope
doxazosin
Cardura 16mg for HTNCardura 8mg for BPH
terazosin
Hytrin 20mg for HTNHytrin 10mg for BPH
prazosin
Minipress 5mg BID or TID for HTN + BPH
alpha-1 blockers for BPH
doxazosin [Cardura], terazosin [Hytrin], prazosin [Minipress], tamsulosin [Flomax], alfuzosin [Uroxatral], sildosin [Rapaflo]
alpha-2 agonists
ADE = fatigue, depression, impotence, bradycardia, rebound HTN [taper over 2-5 days]
clonidine
Catapres 0.1-0.3mg BID
methyldopa
Aldomet 500mg BID [max = 3000mg/day] ADE = DILE, hemolytic anemia, hepatitis
guanfacine
Tenex, Intuniv
guanabenz
Wytensin
direct vasodilators
ADE = reflex tachycardia, DILE [hydralazine], hair growth [minoxidil]
hydralazine
Apresoline 75mg QID
minoxidil
Loniten 40mgRogaine for hair growth
adrenergic neuron blockers
ADE = depression, bradycardia
reserpine
Serpasil 0.05-0.25mg
IV for hypertensive crisis
enalapril, labetalol, esmolol, nicardipine, clonidine, hydralazine, phentolamine [Regitine; non-selective alpha-blocker], nitroprusside [Nipride; direct vasodilator], nitroglycerin [Tridil; direct vasodilator] nitroprusside → most effective [rapid onset]nitroglycerin → NO PVC bag [only glass bottles]
antihypertensives for pregnancy
First-line = labetalol [Normodyne, Trandate], methyldopa [Aldomet]Second-line = nifedipine [Adalat, Procardia]