Disorders of Male Reproductive System

What are the testes composed of?

seminiferous tubules and interstitial tissue

Where is sperm produced?

seminiferous tubules

Where is testosterone produced?

interstitial tissue of testes

Which cells regulate sperm production?

setoli cells

Where does sperm maturation and storage occur?

epididymis

What gland excretes nutrient fluid into semen?

seminal vesicles

What enzyme causes semen to clot after ejaculation?

vesiculase

Which two glands provide add nourishing fluid for the sperm?

seminal vesicles and prostate

What is the inability to attain or sustain an erection firm enough for satisfactory intercourse?

erectile dysfunction

What disorder is caused by either slow arterial inflow or fast venous drainage to corpus cavernosum?

erectile dysfunction

What is the result of impaired spermatogenesis?

low sperm count - below 15 million/mL

What is the presence of no sperm in semen?

azoospermia

What are the three primary causes of azoospermia?

testicular azoospermia, post-testicular/obstructive azoospermia, pretesticular azoospermia

What is a birth defect in boys in which the opening of the urethra is located ventrally on penis?

hypospadias

What is the birth defect in which the opening of the urethra is located on the dorsum of the penis?

epispadias

What is the inability to retract the foreskin over glans in uncircumcised males?

phimosis

What occurs when a forcibly retracted prepuce becomes trapped, producing glans congestion, edema, pain, and urinary obstruction?

Paraphimosis

What is the inflammation of the glans?

balanitis

What is the most common cause of balanitis?

fungal infection

What is the inflammatory disease w/ a white, sclerotic patch at tip of glans which can constrict urethral opening?

balanitis xerotica obliterans

What is the sexually transmitted cauliflower-like growth on the glans caused by HPV?

condyloma acuminatum

What is a squamous carcinoma that forms a grayish or reddish plaque on glans?

Bowen disease

What is the distortion of an erect penis from fibrous scar tissue of the corpus cavernosum?

peyronie disease

What is a prolonged erection of the penis due to impaired venous outflow from inflammation or drug therapy?

priapism

What is the inflammation of the urethra primarily caused by infection?

urethritis

What is the protrusion of the bowel into the inguinal canal or scrotum through a weak spot in abdominal muscles?

inguinal hernia

What is a fungal infection that causes red and itchy rash in warm and moist areas around the scrotum/inguinal skin?

Tinea cruris (jock itch)

What is the condition in which veins become enlarged inside the scrotum?

varicocele

What is the accumulation of fluid in the sac of the tunica vaginalis that surrounds the testis?

hydrocele

What is the congenital condition in which one or both of the testis fail to descend from the abdomen into the scrotum?

cryptorchidism

What is the concern with a non-descending testicle?

10x risk for testicular malignancy and non-functioning testes

What is the swelling of the testes from inflammation?

orchitis

What is the inflammation of the epididymis?

epididymitis

What symptoms differentiate orchitis and epididymitis?

testicular pain and tenderness more severe in epididymitis

What are cysts of the epididymis that contains sperm?

spermatocele

What is the twisting of the spermatic cord from rotation of the testicles?

testicular torsion

What disorder is associated with intense scrotal pain, swelling, N & V?

testicular torsion

What is the surgery to move and/or permanently fix a testicle into the scrotum?

orchipexy

Are the majority of testicular neoplasms benign or malignant?

malignant

What are the two major groups of testicular neoplasms?

germ cell tumors and sex-chord/stroma cell tumors

What is a neoplasm that grows as a mass of disorganized tissues?

benign teratoma

What germ cell tumor is the most common that grows and metastasizes slowly?

seminoma

What makes the germ cell tumors unique?

they stem from totipotent cell so they can grow into anything

What diagnostic measure is contraindicated in germ cell tumors in men?

biopsy - do not want to breech inherent barrier of testes that prevents spread of malignancy

What neoplasms arise from primitive embryologic sex-chord stromal cells?

sex chord/stromal tumors

Which tumors arise in testicular stroma?

leydig cell tumors

Which tumors arise in seminiferous tubules?

sertoli cell tumors

What is the prostate's primary function?

produce seminal fluid that nourishes and transports sperm

What hormone is required for the prostate to maintain its function?

androgen

What is the role of prostate specific antigen (PSA)?

dissolves clotted semen and allows sperm to migrate upward into female genital tract

Where does prostate cancer typically develop?

posterior and peripheral region

What is the issue with antibiotic treatment in bacterial prostatitis?

antibiotics do not penetrate tissue well - gland harbors reservoir of organisms that are difficult to completely eradicate - recurrent acute or chronic prostatitis

What is caused by nodular hyperplasia of the prostate gland and supporting tissue?

benign prostatic hyperplasia (BPH)

What is the malignancy of the prostate gland epithelial cells?

prostatic carcinoma (adenocarcinoma)

What is the stimulus for continued growth of prostatic carcinoma?

adrogen

What is the neoplastic growth of epithelial cells within preexisting benign prostatic acini or ducts?

prostatic intraepithelial neoplasia (PIN)

What is the common site of metastasis for prostate cancer?

bone