Positive co-stimulatory interactions 40
B7----CD28CD40----CD40L
Negative co-stimulatory interactions
PD-L1 ------ PD-1B7(CD80)----- CTLA4
Th1: intracellular
up regulate NK cells, activate CD8 cells/macrophages, up regulate TH1 (autocrine fashion), B cells switch to IgG3
what do TH1 cells release
IL2, IFN gamma
TH17 cells
involved in autoimmune diseases
what do TH17 cells release
IL17, IL21, IL22
TH2 cells (extracellular)
influence IG isotype (G and A), influence plasma vs memory, B cell differentiation, eosinophil and basophil recruitment
TH2 releases
IL-4,5,10,13
regulatory T cell releasesreceptors
TGFbeta, IL-10, IL-4 CD25, Fox P3