MED-Acetminophen

Functional Class

AnypyreticAnalgesic

Mechanism of Action

Analgesia: Elevates pain threshold. May block pain impulses by inhibition of prostaglandin synthesisAntipyretic: Inhibition of prostaglandin synthesis in CNS. No anti-inflammatory or anti-platelet properties.

Indications

Fever

Contraindications

Hypersensitivity to acetaminophen or phenacetin

Precautions

AnemiaHepatic/Renal diseaseAlcoholism

Side Effects

N/VDizzinessHepatotoxicityRenal FailureHypoglycemia

Interactions

Increased risk of hepatotoxicity when taken chronically with alcohol, rifampin, carbamazepine, barbituates

Dose and Route

Adult: 325-650 mg PO/PR q 4-6 hoursPedi: 15 mg/kg PO/PR q 4-6 hrs