Biochem Drugs/Proteins

RifampicinRifamycin

Inhibits initiation of RNA synthesisBlocks formation of first phosphodiester bond

Actinomycin D

Inhibits RNA synthesis by incalating DNACauses mutationsWorks in both pro- and eukaryotes

Alpha-amanitin

Inihibits eukaryotic RNA polymeraseRNA pol I - (nucleolus) insensitiveRNA pol II - (mRNA) highly sensitiveRNA pol III - (tRNA) moderately sensitive

Antibiotics to bacteria

Inhibit protein translationAct of rRNA, not the ribosomal protein

Diphtheria toxin

Inihibits translocation of protein being synthesized

Puromycin

Causes premature chain terminationActs like aminoacyl-tRNAAffects both pro- and eukaryotes

Streptomycin

Inhibits initiation and causes misreading of mRNA in prokaryotes