Class
Cholinesterase Reactivator , (2 PAM)
Pharmacology and Actions
Reactivates the cholinesterase inhibited by phosphate esters by displacing the enzyme from its receptor sites. This restores the normal functions of the neuromuscular transmission.
Indications
An antidote and treatment for organophosphate poisoning
Contraindications
Severe Cardiac DiseasePeptic UlcerAsthmaMIHypersensitivity to Procainamide / Procaine
Precautions and Side Effects
TachycardiaHypertensionDizziness
Dosage (Adult)
1-2 grams in 250-500ml of NS infused over 15-30 mins ; if no IV access is available 1-2 grams IM / SC