animal hormones

How does a negative feedback system work?

Sensor monitors the variablecontrol center compares magnitude of variable to the setpoint value, integrates the information, and controls the response of the effector system(s), which control the magnitude of the variable, bringing it back to set point

what are the two primary types of controls of effectors in multicellular animals, and what do they do?

nerve cells that produce electrical impulses (that usually transmit information via neurotransmitters)hormones that provide chemical signals

What do chemical messages such as hormones do?

they produce and coordinate anatomical, physiological, developmental and behavioral changes

Where do hormones come from?

they are secreted by endocrine cells (often in endocrine glands)

What is the difference between hormones and nerve impulse transmission?

Hormones work much more slowly than nerve impulse transmission and are not useful for controlling rapid actionshormones coordinate longer-term developmental processes such as reproductive cycles

Endocrine

cells or glands that do not have ducts leading to the outside of the body; they secrete their products directly into the extracellular fluid

Exocrine glands

have ducts that release their secretions into the gut, etc.

Are all endocrine cells part or a gland?

No, some endocrine cells are single cells within a tissuedigestive hormones, for example are secreted by isolated endocrine cells in the wall of the stomach and small intestine

endocrine glands

Some endocrine cells aggregate into secretory organs called endocrine glands

Endocrine system

In vertebrates, nine major endocrine glands make up the endocrine system

endocrine cells

hormone secreting cells

target cells

cells receiving the hormonal messages, they must have appropriate receptorsthe binding of the receptor activates a response

what characteristic determines hormone groups?

The distance over which teh signal operates distinguishes hormone groupssome act close to the release site, others at distant body locations

circulating hormones

most hormones diffuse into the blood, which distributes them throughout the bodywhen the hormone message encounters a cell with the proper receptor, it binds and triggers a response

What does the position on/in a cell of a receptor tell you about the hormone?

It can tell you if it is water or lipid soluble and if it can diffuse across the cell membrane

Local hormones

act locallytwo types: autocrine, paracrine

Autocrine hormones

act on the secreting cell itself

Growth factors

stimulate growth and differentiation of cells, are a major class fo paracrine hormonesalso act as autocrine hormones: some of the hormone influences the cell that secreted it, preventing the cell from secreting too much hormone

What are some major types of local hormones

growth factorsneurons may also be considered to be paracrine cells because they use chemicals called neurotransmitters to send messages to another cell

Paracrine hormones

act on cells near the site of releasereleased in tiny amounts or inactivated rapidly by enzymes, or are taken up efficiently by local cellsthey never get into the circulatory system

What are the three main groups of hormones based on structure?

peptides or protienssteroid hormonesamine hormones

peptide or protein hormones

water solubletransported by vesicles out of the cell that made themtheir receptors are on the outside of the cell membrane of the target cell (they can't get into the cells)

steroid hormones

lipid-solublecan diffuse out of the cells that made themin the blood they must be bound to carrier proteinsbc they can diffuse through the cell membrane their receptors are usually in the cytoplasm of the target cells

amine hormones

derivatives of the amino acid tyrosinemost are water-soluble, but some are lipid-soluble

lipid-soluble hormones

the receptors for lipid-soluble hormones are inside cells, either in the cytoplasm or in the nucleusthe action of lipid-soluble hormones is mediated by intracellular hormone receptors that usually alter gene expression

water solublble hormone receptors

large glycoproteins on the cell surface with three domains

What are the three domains of water-soluble hormone receptors?

binding domain: projecting outside the plasma membranetransmembrane domain: anchors the receptor in the membranecytoplasmic domain: extends into the cytoplasm of the cell

How does the cytoplasmic domain initiate the target cells respone?

It activates protein kinases or protein phosphotases (signal transduction cascades)

What determines how a cell responds to a hormone?

responses to hormones depend on their receptors and target cellsthe same hormone can cause different responses in different types of cells

How does epinephrine act on different cells in the body?

in the heart, it stimulates faster (increases HR) and stronger (increases stroke volume) heartbeat (increase cardiac output)blood vessels in some areas (gut, skin, etc.) constrict to send more blood to skeletal musclesin the liver, glycogen is broken down to glucose to provide quick energyin fat tissues, fats are mobilized as another energy source, fatty acids

When in evolution did hormones arise and how do we know?

hormonal comunication arose early in evolutionall multicellular animals have chemical communication between cells, even spongesplants also have hormones, mainly to control growty and development

why must insects molt?

because insects have rigid exoskeletons, they have episodic growth patterns and must molt periodically

instar

the growth stage between each molt

How is molting regulated in insects

two hormones, brain hormone and ecdysone (molting hormone) work together to regulate molting

corpora cardiace

pair of structures attached to the insect brain that store brain hormone

prothoracic gland

endocrine gland in the thorax of insects which receives brain hormone and releases ecdysone which stimulates molting

corpora allata

the rear part of the insect headproduces juvenile hormone

juvenile hormone

prevents molting to the adult stageif it is present the insect molts into another juvenile instar

complete metamorphosis

larva-->pupa-->adult

pituitary gland

a link between the nervous system and many endocrine glands and plays a crucial role in the endocrine systemthe pituitary gland sits in a depression at the bottom of the skull and is attached to the hypothalamusmade of two parts: anterior and posterior

Posterior pituitary (neurohypophysis)

an extension of the hypothalamus and therefor neural tissuereleases 2 hormones: ADH, oxytocin

Where are the hormones from the posterior pituitary made and how do they get into the gland?

they are made by neurons in the hypothalamus (and therefore are neurohormones) an are packaged in vesiclesthe vesicles are transported down the axons of the neurons that made them and are stored in the posterior pituitarythis movement of vesicles is achieved by kinesin proteins, powered by ATP, that "walk" down the microtubules of the axon

anterior pituitary (adenohypophysis)

forms from an inpocketing of the roof of the mouth (Rathke's pouch)releases four tropic hormones which control (stimulate) activities of other endocrine glandsthey are peptide and protein hormoneseach is produced by a different type of pituitary cellother peptide and protein anterior pituitary hormones influence tissues that are not endocrine glands

Antidiuretic hormone (vasopressin)

the major function is to increase water conservation by the kidneyIf there is a high level of ADH secretion, the kidneys reabsorb water, decreasing urine outputADH stimulates increased aquaporins in the collecting ductsif there is a low level of ADH secretion, the kidneys release water in dilute, high volume urineADH release by the posterior pituitary increases if blood pressure falls or blood becomes too saltyADH also causes peripheral blood vessel constriction

oxytocin

a major function of oxytocin is to stimulate uterine smooth muscle contraction for the birth process (Pitocin)it also stimulates milk flow (stimulates smooth muscle for ejection of milk) in the mother's breasts

What are the four types of tropic hormones?

thyrotropinadrenocorticotropingonadotropinslutenizing hormone and follicle stimulating hormone

What nontropic hormones are produced by the anterior pituitary?

growth hormoneprolactinmelanocyte-stimulating hormoneendogenous opiodes endorphines and enkephalins

growth hormone

acts on many tissues to promote growthstimulates cells to take up amino acidsstimulates the liver to produce chemical messages (insulin-like growth factors) that stimulate bone and cartilage growth

gigantism

the result of overproduction of GH in children

pituitary dwarfism

caused by the underproduction of GH GH can now be produced by genetically engineered bacteria

Prolactin

stimulates the production and, to a lesser extent, secretion of milk in female mammalsit is also important in pregnancy and, in males, has a role in controlling the endocrine functions of the testes

endorphins and enkephalins

the body's natural opiatesin the brain, these molecules act as neurotransmitters to reduce pain in pain pathways

What controls the anterior pituitary and how?

the anterior pituitary is controlled by neurohormones from the hypothalamusthe hypothalamus obtains data about body conditions and the external environment through both neuronal and hormonal signalsthe hypothalamus and the anterior pituitary are connected by portal blood vesselssecretions from the hypothalamic nerves are transported by these blood vessels to the anterior pituitary

Thyrotropin-releasing hormone (TRH)

from the hypothalamuscuases anterior pituitary cells to release thyrotropin, which in turn stimulates the thyroid gland

gonadotropin-releasing hormone (GnRH)

causes the anterior pituitary to release tropic hormones that control gonad activity (follicle stimulating hormone and luteinizing hormone)

What type of feedback system controls anterior pituitary cells and the hypothalamus?

They are under negative feedback control by the hormones of the glands they stimulate

Cortisol feedback system

cortisol is produced by the adrenal gland in response to adrenocorticotropin. It returns to the pituitary in the blood, and inhibits further release of adrenocorticotropinCortisol also exerts negative feedback control on the hypothalamu, inhibiting release of adrenocorticotropin-releasing hormonehowever, higher brain input to the hypothalamus also controls circulating anterior pituitary hormone levels

Thyroid gland

located near the tracheaanother example of an endochrineproduces the hormone thyroxine in specialized structures called follicles

thyroxine

two active forms T3 and T4 are made from tyrosineT3: 3 IT4: 4 Imore T4 is produced, but its can be converted to T3 by an enzyme in the bloodT3 is the more active form of the hormone

Roles of thyroxine in metabolism

it stimulates the transcription of many genes in nearly all cells in the body. Theses include genes for enzymes of energy pathways, transport proteins, and structural proteinsit elevates metabolic rates in most cells and tissues (important in thermoregualtion)it raises blood glucose and promotes the use of carbohydrates over fats for fuel

Cretenism

Irreversible neural damage and retardation caused by insufficient thyroxine after the 4th month of human fetal life which results in inadequate formation of the myelin sheath around the axons of neurons

Controls of thyroxine

Thyrotropin (or TSH) from the anterior pituitary activates thyroid gland cells to produce thyroxineThyrotropin-releasing hormone (TRH) from the hypothalamus activates TSH-producing cells in the anterior pituitaryIn a negative feedback loop, thyroxine inhibits the response of pituitary cells to TRH. Therefore, less TSH is released when levels are high, and more is released when levels are lowThyroxin also feeds back to reduce TRH from the hypothalamus

Goiter

an enlarged thyroid gland associated with eigher very low (hypothyroidism) or very high (hyperthyroidism) levels of thyroxine

What is the structure of a thyroid follicle?

a thyroid follicle is a layer of epithelial cells surrounding a mass of glycoprotein called thyroglobulin

Thyroglobulin

contains iodinated tyrosines and is digested by the epithelial cells of the follicle to make thyroxine

What happens if there is inadequate iodine present when thryoglobulin is made?

the released molecules will be neither T3 nor T4 and will not bind to appropriate receptors (including those in the hypothalamus and anterior pituitary)Goiter occurs when thyroglobulin production is above normal and the follicles are enlarged

Hypothyroid goiter

results when there is insufficient thyroxine to turn off TSH productionthe most common cause is a deficiency of dietary iodinewith high TSH levels, the thyroid gland continues to produce nonfunctional thyroxine and becomes very largethe body symptoms of this condition are low metabolic rate, cold intolerance, and physical and mental sluggishness

hyperthyroid goiter

results when the negative feedback mechanism fails even though blood levels of thyroxine are hight. A common cause is an autoimmune disease in which an antibody to the TSH receptor is produced. Common symptom is high metabolic rate.

What three hormones control blood calcium

calcitonin, parathyroid hormone and vitamine D

Blood calcium regulation processes (3)

Deposition and absorption of bone exceretion of calcium by hte kidneys Absorption of calcium from the digestive tract

Calcitonin

released by the thryroid gland acts to lower calcium levels in the bloodCalcitonin decreases osteoclast activity and stimulates the osteoblasts to take up calcium from the blood for bone growth

Osteoclasts/Osteoblasts

Osteoclasts break down bone and release calcium to the bloodOsteoblasts secrete the protein matrix and use circulating calcium to build new bone. As bone is laid down the osteoblasts are surrounded and develop into osteocytes.

parathyroid glands

embedded in the posterior surface of the thyroid gladreleases parathyroid hormone when blood Ca is low

parathyroid hormone (PTH)

causes the osteoclases to dissolve bone and release calciumpromotes calcium resorption by the kidney to prevent loss in the urinepromoting vitamin D activation which stimulates the gut to absorb calcium from foodActs on the kidneys to increase the elimination of phosphate to reduce the possibility of calcium phosphate salt precipitation (kidney stones)

vitamin D

not actually a vitamin, produced by the bodyactivates to form (1,25) dihydroxyvitamin D, stimulated by PTHThe active form binds to cyctoplasmic receptors and forms transcription factors. in the digestive tract the transcription factors act to increase synthesis fo calcium pumps, calcium channels and calcium binding proteins, promoting uptake of calciumIn the kidneys and bone acts like PTHNegative feedback to inhibit PTH

medulary bone

bone stored in egg laying female birds to store calcium , under the control of PTH

Pancrease

insulin and glucagon are produced in the pancrease in cell clusters called islets of Langerhans

Insulin

required for glucose uptake by most cells but not nerve cellsinhibits lipase (lipid breakdown) in adipose tissue, and stimualtes amino acid uptake by cells

Diabetes mellitus

type 1 - lack of the protein hormone insulintype 2 - lack of insulin receptors on target cellscauses excessive urine production

Diabetes insipidus

hyposecreation of ADH (makes you pee more)

glucagon

stimulates liver to convert glycogen to glucose when glucose levels are low

somatostatine

paracrine functions that inhibit both insulin and glucagonslows the gut activitesinhibits release of GH and thyrotropin

Andreanl glands

made up of adrenal medulla and the adrenal cortex two seperate endocrine organs

andrenal medulla

produces epinephrine and norepinephrinedevelopes from the nervous system and is under the control of the nervous system

adrenal cortex

under hormonal control mainly by adrenocorticotropin (ACTH) from the anterior pituitary

beta blockers

prevent epi from binding to the beta-adrenergic recptors on target cellsused to reduce fight-or-flight response for heart patients leaves alpha sites open for regulatory function

corticosteroids

prodcues by the adrenal cortex using cholesterolacts by stimulating transcription of certain genesglucocorticoidsmineralocorticoidsSEX steroids

glucocorticoids

raise blood glucose concentrations and other aspects of fuel molecule metabolism

mineralocorticoids

infulence extracellular ionic (mainly Na and K) balance

SEX steroids

stimualte SEXUAL developement and reproductive activity. Under normal conditions theses are secreated in only minimal amounts by the adrenal cortex

aldosterone

the main mineralocoritcoid stimulates the kidney to conserve sodium and excrete potassiumrelease is stimulated by angiotensin-II

Renin

release is stimulated by lo blood Na and or lo blood pressure

Cortisol

the main glucocorticoid helps control blood levels of glucose and other energery sources and to mediate the body's response to stressraises blood glucose by stimulating gluconeogenesis by the liver and inhibiting peripheral use of glucose (saving for neural tissue) mobilizes fatty acids from adipose tissue and increases blood (amino acid) from muscle for uptake and use in gluconeogenesisstress response ensures that muscles have enough glucose for immediate response and brain has enough glucose to functionalso blocks the immune system reactions which temporarily are less critical, can be used to reduce inflammation and allergy

ACTH-RH

from the hypothalamus to stimulate the release of ACTH which controls cortisol levels

gastrin

stimulates secretion of HCl and pepsin, increases motility of stomach

Enterogastrone

slows the movement of the stomach

secretin

releases bicarbonate solution from pancrease to neutralize HCl before it enters the intestines

Luteinizing hormone (LH) and follicle-stimulating hormone (FSH)

controls the SEX steroids released by the anterior pituitary

Gonadotropin-releasing hormone (GnRH)

released by the hypothamalus to stimulate the release of gonadotropins (LH and FSH)

How/why does puberty start

Starts when the hypothalamus becomes less sensitive to negative feedback by the SEX steroids

corpus luteum

remaining follices left over in the ovary during ovulation that function as an endocrine gland and produces estrogen and progesterone for about two weeks

Estrus

the state of sexual receptivity around the time of ovulation

human chorionic gonadatropic (hCG)

similar to funcion in LH but only produced by cells covering the blastocystdetected by pregnancy tests

metlatonin

produced by the pineal gland, released in dark