Toxicology Thrapeutic Drugs and Ranges

What is the therapeutic range for Theophylline? what is the toxic range for theophylline?

Therapeutic: 10 - 20 ug/mLToxic: >25 ug/mL

What are the effects of Theophylline?

Muscle Relaxant. Stimulates CNS; Increases respiratory rate

what is the therapeutic range for Digoxin, and when does it become toxic?

Therapeutic: 0.8 - 2.0 g/mLToxic: >3.0 g/mL

what are the effects of Digoxin?

Improve cardiac contractions in CHF

what is the therapeutic dose for Lidocaine and when does it become toxic?

Therapeutic: 1.5 - 5.0 ug/mLToxic: >5 ug/mL

what are the effects of Lidocaine?

Correct ventricular arrhythmias

what is the therapeutic dose for Phenobarbital and when does it become toxic?

therapeutic: 15 - 40 ug/mLtoxic: N/A

what are the effects of Phenobarbitol?

treats febrile seizures and neonatal seizures

what is the therapeutic dose for valpruic acid and when does it become toxic?

therapeutic: 50 - 100 ug/mLtoxic: > 100 ug/mL

effects of valpruic acid

treatment for petit mal and myclone seizures

what is the therapeutic range for Chloramphenicol and when does it become toxic?

therapeutic: 10 - 20 ug/mLtoxic: >25 ug/mL

what are the effects of Chloramphenicol?

multi purpose antibiotic (primarily aplastic anemia)

what is the therapeutic range for vancomycin and when does it become toxic?

therapeutic: trough (5 - 10 ug/mL) peak (30 - 40)toxic: trough (>20) Peak (>80)

what are the effects of Vancomycin?

antibiotic against GPC and GPR

what is the therapeutic dose for Cholinesterase and when does it become toxic?

therapeutic: 4,000 - 12,000toxic: N/A

what are the effects of cholinesterase

secondary to insectiside exposure; insecticide poisoning

what is the therapeutic dose for Salicytate and when does it become toxic?

therapeutic: <30 mg/dL toxic: >30 mg/dL

what are the effects of Salicytate?

analgestic (respiratory acidosis)

what is the therapeutic dose for acetaminophen and when does it become toxic?

therapeutic: 10 - 25 mg/dL toxic: 100 - 250 mg/dL

what are the effects of acetaminophen?

delays toxicity due to liver necrosis 3 - 4 days post