Cancer

Examples of SARMs?

FlutamideBicalutamide

Rare AE related to flutamide?

Liver toxicity. Reversible, but Liver fx should be monitored.

Examples of BRM?

Cytokines:Interleukin-2Alpha interferonTopical agent:Imiquimod (Aldara)

Interleukin AE?

Fluid retentionSkin changesKidney fx

Examples of antibodies

HerceptinTrastuzumabRituximabBevacizumabCetuximab

Herceptin dose

LD= 8mg/kg followed by 2mg/kg weekly orLD= 8mg/kg followed by 6mg/kg q3 weeks

Antibody that can cause tumor lysis syndrome and fatal infusion rxns

Rituximab

Examples of enzyme inhibitors and receptors down regulators?

AnastrozoleExemestaneFulvestrantLetrozole

Synthetic analog of progesterone used as additional hormonal treatment?

Megestrol

In case of extravasation use warm compression

Vinka alkLoids

Lomustine PO or IV?

PO

After infusion the urine may have a temporary blue-green tinting and sclera may turn blue

Mitoxantrone

Lifetime dose for epirubicin?

900mg/m2

Lifetime dose for doxarubicin and daunorubicin?

550mg/m2

Needs premed with phenytoin to prevent seizures?

Busulfan

Give dexamethasone ophthalmic to prevent conjunctivitis

Cytarabine

Tablet that converts to 5-FU

Capecitabine

Can cause hand and feet syndrome (palmar-plantar erythrodysethesias)?

5-FU

Folic acid increase or decrease the effect of MTX?

Decrease

Give dexamethasone ophthalmic to prevent conjunctivitis

Cytarabine

Avoid cold drinks or food during infusion due to spasm

Oxaliplatin

Fatal if given intrathecal

Vincristine

Do not PVC bag

Paclitaxel and docetaxel

Can cause pulmonary fibrosis and lifetime dose is 400units

Bleomycin

Rapid infusion causes HTN. Also increases coumadin INR

Etoposide

Drugs that can cause hemorrhagic cystitis

Cyclophosphamide and ifosfamide

Dose of Mesna to prevent hemorrhagic cystitis with Ifex

20% of ifex dose

Can cause kidney damage . So pre hydrate with K and Mg

Cisplatin

Given with leucovorin to increase it's activity

5-FU

How to diagnose colon polyps

CT colonographyFOBTColonoscopy

Risk factors for lung cancer

SmokingChronic lung diseaseAsbestosRadonFhx of lung cancer

Risk factors for colon cancer

FhxAgeDietObesitySmoking

Major colorectal cancer susceptibility syndromes are

Familial adenomatous polyposis(FAP)Hereditary non- polyposis colorectal cancer (HNPCC)

Carcinogens highly associated with lung cancer

BenzopyreneN-nitrosamine NNK

Most common type of noninvasive breast cancer

Ductal carcinoma in situ

Most common type of breast cancer

Infiltrating ductal carcinoma

Hypercalcemia in malignancy treatment

Pamidronate disodiumZolendric acid

Given as CIV 1mg/ml infused > 1h

Cisplatin

Administered along with MTX to reduce anemia

Leucovorin

Fludarabine main side effect

Strong bone marrow suppressor

Given IV over 30 min

Gemcitabine

Given intravesical to treat small bladder papilloma

Mitomycin C

Can cause diarrhea and abdominal cramps (life threatening)

Irinotecan. Give loperamide 4mg first onset, 2mg q2hs until diarrhea free for 12h. Atropine 0.25-1mg IV for prophylaxis

Pre-med for paclitaxel

Decadron 20mgIVBenadryl 50mg IVZantac 50mg IV

Risk factors for breast cancer in men

FhxAlcoholRadiotherapyTesticular abnormality or damageLiver damage or dysfunctionObesityKlinefelter's syndrome

Prostate cancer risk factors

FhxAgeRaceDiet

Metabolic abnormalities of TLS

HyperkalemiaHyperuricemiaHyperphosphatemia with secondary hypocalemia

TLS is seen more often in which kind of tumors?

Tumors with high growth factor and high sensitivity to chemo (burkitt lymphoma and T cell acute lymphoblastic leukemia)

Main types of lymphedema?

Primary and secondary

Class of drugs hepatically adjusted according to bilirrubin level

Vinca alkaloids

Antetabolites that can be given as IV push

MTX5-FUCytarabine

Drugs with high emetic risk

AC combinationCarmustine > 250mg/ m2Cisplatin >= 50cyclophosphamide > 1500AltretamineDacarbazineMechloretamineProcarbazineStreptozocin

Treatment for low risk emetic chemo

Metoclopramine +/- diphenhydramine orDexamethasone 12mg orProchlorperazine +/- lorazepam

Types of lung cancer

Small cell and non-small vell

Kinds of non-small lung cancer

Squamous cell carcinomaAdenocarcinomaLarge cell carcinoma

Which of the non-small cell lung cancer is associated with rapid tumor growth and poor prognosis

Large cell carcinoma

Lung cancer that develop in the central region of the lungs

Squamous cell carcinoma

Advanced lung cancer symptoms

Persistent coughSputum streaked with bloodChest painVoice changeRecurrent pneumonia or bronchitis

Common types of polyps

AdenomatousHyperplasticInflammatory

Lynch syndrome is also known as

Hereditary non-polyposis colorectal cancer

Dietary factors associated with decreased risk of colorectal cancer

Diet rixh in fruits and vegetables and calcium

Symptoms associated with advanced stages of colorectal cancer

Rectal bleedingBlood in the stoolChange in bowel habitsCramping pain in lower abdomen

What's the difference between in situ breast cancer and infiltrating

Insitu is confined to ducts and lobules of breast, while invasive spreads to the surrounding connective tissue

Breast cancer risk factors

Hx of breast cancerFhxAgeDietRaceRadiation exposureReproductive and menstrual hx

Ptns thy impact cancer risk

Alpha-fetoproteinhCG

Sumptoms of breast cancer in men

Painless lump in the breastNipple retraction, discharge or ulcerationPainful lump in the breastPaget's disease (skin rash around nipple)

Majority of breast cancer in men is

Invasive ductal carcinoma and ER positive

Dietary factors associated with prostate cancer

Diet rich in dairy and meat are associated with higher riskDiet rich in fish and tomato based products are associated with lower risk

Prostete cancer symptoms associated with late stage

Inability to peeDiscontinuous or weak urine flowFrequent urinationBlood in urinePain or burning with urinationContinuous back, pelvis or upper thigh painDifficulty in starting or stopping urine flow

Monoclonal antibody used to treat of squamous cell carcinoma of Rhadamanthus and neck that can cause dermatological toxicity such as acne like rash, pruritus and nail changes

Cetuximab

MAB that binds to VEGF

Bevacizumab

Anthracycline that can cause stomititis

Doxarubicin - tx with saline rising anf magic mouth wash + lidocaine

Chemo agents that can be given intrathecal

MTXCytarabine

Chemo drug that can be given intravesical

Mytomycin C for small bladde papilloma

Chemo drug that can be given Icav

Bleomycin

Chemo drug that can be given PO

6-MPChlorambucilCapeciyabineHydroxyureaLomustineTemozolomideBusulfanCyclophosphamideMelphalan

Taxan can cause hypersensitive most likely us to

CHEMAPHOR

BRM currently under investigation as a possible angiogenesis inhibitor

Alpha interferon

Don not give carboplatin if CrCL

<15

Examples of tumor suppressor genes

p53BRCAAPCRb