The large intestine and disorders

What is the function of the large intestine?

Absorb waterImmune function

Outline the immune function of the GIT.

Oral tolerance. New foods taken in, that would cause an immune response if injected.Mucosal immune cells bind the antigens and take them into the blood, signalling to the CNS that they are safe.The epithelial cells provide a barrier so that the antigens can't enter the blood on their own.Gut is in a constant state of controlled inflammation.

What happens in inflammatory bowel disease?

The antigens flood through the leaky epithelial cells and cause an immune response, releasing TGFa , a proinflammatory agent that promotes massive inflammation. This inflammation causes further epithelial damage.

Name 3 treatments of IBD.

1. Glucocorticoids-general anti inflammatories2. Anti- TNFa drugs-monoclonal antibodies bind TNFa and neutralises it3. Sulfosalazine-high efficacy-mechanism unknown

Name examples of inflammatory bowel diseases.

Crohn's DiseaseUlcerative Colitis