DM-CHEAT


Inducers P450

(2)


-Rifamycins-Griseofulvin


Inhibitors P450

(3)


-Macrolides except Azith, Dirith-Quinolones
-2D6


Inducers CYP3A4

(1)


-Nevirapine


Inhibitors CYP3A4

(4)


-Streptogramins-Ketolides-Azoles-Ritonavir-Bis(chloroethyl)amines


Depolarize the cell membroane

(2)


-Cyclic lipopeptides-Televanacin


Cross-links DNA

(2)


-Mitomycin-C-Cyclophosphamide


Prolonged Q-T

(2)


-GnRH-ANAagonists-Ketolides


Biphosphorylation via human kinases

(2)


-Cidofovir-Adefovir


IOCWS


Cidal


IOPS

30s

50s


30s-all Broad, ONLY CIDAL is Aminoglycosides

50s-ONLY 2 CIDAL are Steprogramins and Ketolides


IONAS


Cidal


IOCMP


Cidal


AF


Sulfa-Static

Trimethopril-Cidal


Anti-TB

Primary

Secondary


Primary-Cidal EXCEPT Ethambutol

Secondary-Static


SASI


PE-Cidal (Polyenes, Echinocandins)

AF-Static (Flucytosine, Azoles)


SAMI


All Static except Allylamines can be CIDAL against Dematophytes


PAA


CCNS


AM


CCS


NP


All CCS EXCEPT CAM(CAmptothecins, Anthracycliens, Mitomycin)


Chelation


-Tetracyclines-Quinolones