13 ANS drugs


Autonomic nervous system (ANS) function:


Governs involuntary actionsSympatheticParasympatheticNeurotransmitters


Sympathetic


Fight or Flight


parasympathetic


rest and digest


Drugs that affect ANS


1.Adrenergics (sympathomimetics)2.Adrenergic blockers (alpha and beta blockers)3.Cholinergics (parasympathomimetics)4.Cholinergic blockers (anticholinergics)


Adrenergics

Fright, fight, and flight


Sympathetic nervous system (SNS)


Neurotransmitters � catecholamines


�Epinephrine (adrenaline)�Norepinephrine�Dopamine


True or false

adrenergics mimic actions of the SNS
True False


True


Adrenergic Uses


1.Restoring rhythm in cardiac arrest2. Elevating blood pressure in shock3.Constricting capillaries4.Dilating bronchioles in acute asthmatic attacks, bronchospasm, or anaphylactic reactions5.Performing ophthalmic procedures


adrenergic side effects


Palpitations, nervousness/tremors, tachycardia, arrhythmias, hyperglycemia, hypertension, HA/insomnia, tissue necrosis*, anginal pain


Adgrenerics Contraindications or extreme caution


angina, coronary insufficiency, HTN, arrhythmias, angle closure glaucoma, organic brain damage, hyperthyroidism


adgrenergics caution


Carefully check dose (small amounts only), Give SubQ, IM (deltoid), or IV.


adgrenergic administration


SubQIM (deltoid)IV


CNS drugs, beta- adrenergic blockers, alpha adrenergic blockers are all examples of interactions for _______?


adgrenerics


Block action of SNS, Alpha-adrenergic blockers, Beta-blockers, Propranolol (Inderal) are all actions of _______?


adgrenergic blockers


Uses of beta-blockers


�Hypertension�Cardiac arrhythmias�Angina pectoris�Migraine headache


Side effects of Adgrenergic blockers


Hypotension, bradycardia, fatigue or lethargy, N/V, hypoglycemia, confusion.


slow heart rate is a side effect of


adgrenergic blockers


true or false

patients should rise slowly to avoid postural hypotension
True False


true


cholenergics are used for:


Parasympathetic nervous system


Acetylcholine is a type of


- neurotransmitter


drugs that mimic the PNS


�Bethanechol�Neostigmine�Pilocarpine


these actions such as

�Increased GI peristalsis
�Increased contraction of urinary bladder
�Increased secretions (sweat, saliva, gastric juices)
�Increased skeletal muscle strength

are all examples of


cholinergic actions


these actions (Decreased intraocular pressure, Constriction of pupils, Slowing of heart)

are examples of


cholinergic actions


examples of cholinergic uses


�Non-obstructive urinary retention�Non-obstructive abdominal distention�Myasthenia gravis � neuromuscular disorder,muscle weakness (activity).�Open-angle glaucoma


a cholinergic antidote


atropine sulfate IV


N/V/DContraindications or ex, muscle cramps/weakness, slow pulse/BP, sweating, respiratory depression, bronchospasm are all examples of ________?


cholinergic side effects


what type medicatons should cholinergics not be used with?


antibiotics and heart meds


actions such as these are examples of

�Drying (All secretions decreased)
�Decreased GI and genitourinary (GU) motility
�Dilation of pupils


cholinergic blockers


�Uses:
�Antispasmodic and antisecretory for GI or GU
hypermotility
�Preoperative and preanesthetic application
�Neuromuscular block and other spastic
disorders
�Antidote for insecticide poisoning,
cholinergic crisis, or mushroom poisoning


cholinergic blocker


Antidote for insecticide poisoning,
cholinergic crisis, or mushroom poisoning


cholinergic blocker


used for preoperative and preanesthetic application


cholinergic blocker


used in emergency treatment of bradycardia and atrioventricular heart block with hypotension


cholinergic blocker


dilation of pupils


Mydriatic


Patient education for ______

Awareness of possible side
effects, dry mouth, blurred vision.


cholinergic blocker


Contraindications or extreme caution for _______

(w/use of atropine) Asthma, COPD, angle-closure, GI or GU obstruction, arrhythmias, HTN, hypothyroidism, hepatic or renal disease.


cholinergic blocker


Side effects of ______

dry mouth, urinary retention, constipation, confusion tachycardia. blurred vision


cholinergic blocker


anticholinergic drug


atropine


_____ increase gastrointestinal peristalsis and contractions of the urinary bladder


cholinergics


cardiac arrythimias, angina, and migraines can be treated with _______


adrenergic blockers


neostigmine a cholinergic is used to treat what neuromuscular disease


myasthenia gravis


clients taking beta blockers should be instructed to ________ to avoid postural hypotension


arise slowly from a reclining position


how can the bodys sympathetic nervous system best be described


the emergency system


how can the parasympathetic nervous system best be described


resting and digesting system


epinephrine, norepinephrine, dopamine can all examples of


catecholamines


which colinergic blocker is used to prevent motion sickness


Scopalamine(ship = motion sickness)


____ nerve conducts impulses in the thigh and lower leg


sciatic


the major nerve in the PNS


vagus(veggies= rest and digest)


preoperative medication to dry secretions and reduce gastric activity are all uses for


cholinergic blockers


a cholinergic drug used to treat urinary retention not associated with benign prostatic hypertrophy


bethanacol


drugs that mimic parasympathetic responses


adrenergic


drugs that mimic the parasympathetic actions


cholinergic


mediator liberated and synthesized by parasympathetic nerve fibers


acetylcholine


cholinergic used to lower intraocular pressure in glaucoma


pilocarpine


____ dilate to allow a greater oxygen supply


bronchioles


adrenergic administered for severe shock


norepinephrine


classic example of a cholinergic blocker


atropine


adrenergic blocker used for anginas, arrythmias, and migraines


propranolol


most commonly used adrenergic blockers are known as _____ and ______


alpha and beta