acetylsalicylic acid (Aspirin)
COX 1/2 inhibitor - irreversible
Used to reduce inflammation, pain, fever. Also an anti-platelet
AE: bleeding, renal impairment
ibuprofen (Advil, Motrin)
COX 1/2 inhibitor - reversible
Reduces inflammation, pain, fever
Can increase the risk of thrombus
keterolac (Toradol)
Strong IV NSAID
Max 5 day therapy
acetaminophen (Tylenol)
COX-2 inhibition in the CNS
Reduction of pain and fever
morphine
strong opioid analgesic that works primarily at mu-receptors
AE: respiratory depression -> respiratory arrest; N/V;
constipation; etc.
overdose: classic triad - coma, respiratory depression, pinpoint
pupils (may dilate after hypoxic)
methadone
relief of pain, Tx of opioid addiction
AE: prolongs QT interval (ECG before therapy, 30 days into, then
annually), respiratory depression
Long duration, long half-life
codeine
moderate-to-strong opioid
tramadol, tapentadol
Mu-opioid agonist/SNRI
nalaxone (Narcan)
competitive antagonist at opioid receptors
reversal of opioid overdose
IV, IM, SQ, nebulizer, nasal spray
naltrexone
Tx of opioid-induced constipation
IM